ArticleScience immunology2020
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses.
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In one paragraph
Article in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 3 pooled it
23.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
185 citing papers in PubMed, 3 syntheses or guidelines pooled it, 266 citations in OpenAlex.
- Understanding heterogeneity in the pathogenesis and drug responses of ulcerative colitis through single-cell and spatial transcriptomics.Frontiers in immunology · 2026Pooled it
- Single-cell transcriptome landscape of circulating CD4Cell genomics · 2024Pooled it
- Lymphocyte subsets for predicting inflammatory bowel disease progression and treatment response: a systematic review.Frontiers in immunology · 2024Pooled it
- Etrasimod reduces circulating and mucosal inflammatory lymphocyte populations and alters innate immune and non-immune cell signatures in intestinal mucosa: ELEVATE UC phase 3 clinical data.Journal of Crohn's & colitis · 2026Trial
- Crosstalk between the microbiota and intestinal γδ T cell compartments in health and IBD.Gut microbes · 2026Review
- Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial-immune cell interactions.Nature immunology · 2026Article
- Single-cell immune repertoire atlas maps coordinated circulating adaptive immune states in inflammatory bowel disease.bioRxiv : the preprint server for biology · 2026Article
- Article
- Review
- GPR15-guided CD8Nature · 2026Article
- Single-cell spatial transcriptomics of formalin-fixed, paraffin-embedded biopsies reveals colitis-associated cell networks.The Journal of clinical investigation · 2026Article
- Aryl hydrocarbon receptor deficiency triggers the activation of γδT17 cells to exacerbate autoimmune inflammation.Science advances · 2026Article
- CD8MedComm · 2026Review
- Balancing Efficacy and Safety in Multiple Myeloma Patients Receiving B cell Maturation Antigen-Directed CAR T-Cell Therapy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- Multidimensional dissection of shared genetic susceptibility in ulcerative colitis and colorectal cancer: novel insights from integrative single-cell and multi-omics analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Multivariable genome-wide analysis elucidates the shared genetic architecture, immunosenescence features, and gut-origin therapeutic targets of ulcerative colitis-associated multisystem inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026Article
- The roles and heterogeneity of CD8International journal of molecular medicine · 2026Review
- Spatial transcriptomics atlas of inflammatory bowel disease to guide implementation in research consortiums and clinical trials.Nature communications · 2026Article
- Palmitoylation Induced Activation of SMAD3 Exacerbates Colitis by Promoting Tissue-resident Memory T Cells Differentiation.Inflammation · 2026Article
125 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 2 institutions in 3 countries.
Brigid S BolandDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-5360-8816
Zhaoren HeDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-5521-1460
Matthew S TsaiDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-3456-6171
Jocelyn G OlveraDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-4236-1085
Kyla D OmilusikDivision of Biologic Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-3675-048X
Han G DuongDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Eleanor S KimDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-8525-2500
Abigail E LimaryDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Wenhao JinDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-7885-3527
J Justin MilnerDivision of Biologic Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-0752-2130
Bingfei YuDivision of Biologic Sciences, University of California, San Diego, La Jolla, CA, USA.
Shefali A PatelDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Tiani L LouisDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-8608-445X
Tiffani TyslDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-8415-4255
Nadia S KurdDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-0421-9491
Alexandra BortnickDivision of Biologic Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-3431-5193
Lauren K QuezadaDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-2056-6055
Jad N KanbarDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Ara MirallesDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-6454-9911
Danny HuylebroeckDepartment of Development and Regeneration, University of Leuven, Leuven, Belgium.ORCID 0000-0003-4862-1079
Mark A ValasekDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Parambir S DulaiDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Siddharth SinghDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Li-Fan LuDivision of Biologic Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9727-0036
Jack D BuiDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9324-368X
Cornelis MurreDivision of Biologic Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-2437-507X
William J SandbornDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Ananda W GoldrathDivision of Biologic Sciences, University of California, San Diego, La Jolla, CA, USA.
Gene W YeoDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA. changj@ucsd.edu geneyeo@ucsd.edu.
John T ChangDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA. changj@ucsd.edu geneyeo@ucsd.edu.ORCID 0000-0003-0873-6218
University of California San Diego · USErasmus MC · NL
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9MUC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4MSingle-cell approaches to deconvolution of disease-associated signalsU19MH107367 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CALLAWAY, EDWARD M · 2015 to 2019
$15.0MSan Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8MSingle-Cell Transcriptomic and Epigenetics CoreP01AI132122 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2018 to 2022
$9.8MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MTraining Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7MThe 3D-Structures of the Immunoglobulin Heavy Chain LocusR01AI082850 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRE, CORNELIS · 2009 to 2024
$5.4MThe 3D-Structures of the Pre-Pro-B and Pro-B Cell GenomesR01AI100880 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRE, CORNELIS · 2012 to 2022
$4.1MUsing single-cell RNA-seq to interrogate host immunity to pathogensR01AI123202 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, JOHN T, YEO, EUGENE WEI-MING · 2016 to 2020
$3.1MT cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0MRole of proteasome activity in adaptive immunityR01AI129973 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, JOHN T · 2018 to 2022
$2.2MBLRD VA I01 BX003424Intramural NIH HHS Z01 AI000880NCATS NIH HHS KL2 TR001444NCI NIH HHS P30 CA023100NIAID NIH HHS P01 AI132122NIAID NIH HHS R01 AI082850NIAID NIH HHS R01 AI100880NIAID NIH HHS R01 AI123202NIAID NIH HHS R01 AI129973NIAID NIH HHS R37 AI067545NIDDK NIH HHS K23 DK117058NIDDK NIH HHS K23 DK123406NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R21 DK119724NIDDK NIH HHS T32 DK007202NIH HHS S10 OD018499NIH HHS S10 OD026929NIMH NIH HHS U19 MH107367NINDS NIH HHS P30 NS047101
Abstract
Inflammatory bowel disease (IBD) encompasses a spectrum of gastrointestinal disorders driven by dysregulated immune responses against gut microbiota. We integrated single-cell RNA and antigen receptor sequencing to elucidate key components, cellular states, and clonal relationships of the peripheral and gastrointestinal mucosal immune systems in health and ulcerative colitis (UC). UC was associated with an increase in IgG1
Indexed as
Adaptive ImmunityAnimalsColitis, UlcerativeColonHumansImmunoglobulin GIntraepithelial LymphocytesMaleMemory T CellsMice, TransgenicSingle-Cell AnalysisT-Lymphocytes, RegulatoryImmunoglobulin G
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.