ArticleJournal of the American Society of Nephrology : JASN2020
Differentiation of a Contractile, Ureter-Like Tissue, from Embryonic Stem Cell-Derived Ureteric Bud and
Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- In vitro plasticity between ureteric epithelial and distal nephron identity and maturity is controlled by extracellular signals.Developmental biology · 2026Article
- Organoids for tissue repair and regeneration.Materials today. Bio · 2025Review
- In vitro generation of a ureteral organoid from pluripotent stem cells.Nature communications · 2025Article
- Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape.Nature communications · 2024Article
- Production of kidney organoids arranged around single ureteric bud trees, and containing endogenous blood vessels, solely from embryonic stem cells.Scientific reports · 2022Article
- A biomimetic hyaluronic acid-silk fibroin nanofiber scaffold promoting regeneration of transected urothelium.Bioengineering & translational medicine · 2022Article
- Multidisciplinary approaches for elucidating genetics and molecular pathogenesis of urinary tract malformations.Kidney international · 2022Review
- Building human renal tracts.Journal of pediatric surgery · 2022Review
- Renal engineering: strategies to address the problem of the ureter.Current opinion in biomedical engineering · 2021Article
- Connection of ES Cell-derived Collecting Ducts and Ureter-like Structures to Host Kidneys in Culture.Organogenesis · 2021Article
- The origin and role of the renal stroma.Development (Cambridge, England) · 2021Review
- Returning to kidney development to deliver synthetic kidneys.Developmental biology · 2021Review
- Patterning a Ureter Is All in the Stroma.Journal of the American Society of Nephrology : JASN · 2020Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
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Abstract
backgroundThere is intense interest in replacing kidneys from stem cells. It is now possible to produce, from embryonic or induced pluripotent stem cells, kidney organoids that represent immature kidneys and display some physiologic functions. However, current techniques have not yet resulted in renal tissue with a ureter, which would be needed for engineered kidneys to be clinically useful.
methodsWe used a published sequence of growth factors and drugs to induce mouse embryonic stem cells to differentiate into ureteric bud tissue. We characterized isolated engineered ureteric buds differentiated from embryonic stem cells in three-dimensional culture and grafted them into
resultsEngineered ureteric buds branched in three-dimensional culture and expressed Hoxb7, a transcription factor that is part of a developmental regulatory system and a ureteric bud marker. When grafted into the cortex of
conclusionsMouse embryonic stem cells can be differentiated into ureteric bud cells. Grafting those UB-like structures into peri-Wolffian mesenchyme of cultured kidney rudiments can induce production of urothelium and organize the mesenchyme to produce rhythmically contracting smooth muscle layers. This development may represent a significant step toward the goal of renal regeneration.
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