Evidence map›Paper›PMID 32826322›Full record

ArticleJournal of clinical microbiology2020

Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate.

Amin Addetia, Katharine H D Crawford, Adam Dingens, Haiying Zhu, Pavitra Roychoudhury, Meei-Li Huang, Keith R Jerome, Jesse D Bloom, Alexander L Greninger

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04944095 (Serology Testing), which is not on this map. Cited by 394 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
394citing papers in PubMed, 3 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04944095 unknown statusnot on this mapstarted 2021, after this paper: background citation

Serology Testing (Antibody Levels) With Time Following SARS-CoV-2 (Covid-19) Vaccinations in Residents of Nursing, Extended Care, and Over-55 Communities

TypeobservationalSponsorDr. Sidney J. StohsRan2021 to 2024Enrolled10,000ConditionsCovid-19, Subjects Vaccinated Against Covid-19ArmsChange in SARS-CoV-2 Antibody Levels
3 · Its place in the literature

Who cites it

394 citing papers in PubMed, 3 syntheses or guidelines pooled it, 593 citations in OpenAlex.

  1. Pooled it
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  8. Immunogenicity and safety of AZD1222 (ChAdOx1 nCoV-19) against SARS-CoV-2 in Japan: a double-blind, randomized controlled phase 1/2 trial.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
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  13. Early Fc-effector antibody signatures impact COVID-19 disease trajectory.medRxiv : the preprint server for health sciences · 2026
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  18. Hybrid Immunity in a Mozambican Cohort After 1 or 2 Doses of the BBIBP-CorV Vaccine.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
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334 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Amin AddetiaDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
Katharine H D CrawfordDivision of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Adam DingensDivision of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Haiying ZhuDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
Pavitra RoychoudhuryDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
Meei-Li HuangDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
Keith R JeromeDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
Jesse D BloomDivision of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.ORCID 0000-0003-1267-3408
Alexander L GreningerDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA agrening@uw.edu.ORCID 0000-0002-7443-0527
University of Washington · USFred Hutch Cancer Center · USHoward Hughes Medical Institute · US

Funding

Prospectively characterizing the functional and antigenic effects of mutations to viral entry proteinsR01AI141707 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BLOOM, JESSE D · 2018 to 2022
$2.1M
Complete mapping of the functional and antigenic effects of mutations to Lassa virus glycoproteinF30AI149928 · NIAID · UNIVERSITY OF WASHINGTON · PI CRAWFORD, KATHARINE HOLT DUSENBURY · 2020 to 2021
$91k
NIAID NIH HHS F30 AI149928NIAID NIH HHS R01 AI141707
6 · The paper itself

Abstract

The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans. However, to date, studies on protective immunity have been performed only in animal models and correlates of protection have not been established in humans. Here, we describe an outbreak of SARS-CoV-2 on a fishing vessel associated with a high attack rate. Predeparture serological and viral reverse transcription-PCR (RT-PCR) testing along with repeat testing after return to shore was available for 120 of the 122 persons on board over a median follow-up of 32.5 days (range, 18.8 to 50.5 days). A total of 104 individuals had an RT-PCR-positive viral test with a cycle threshold (

Indexed as

Disease OutbreaksAntibodies, NeutralizingAntibodies, ViralBetacoronavirusCoronavirus InfectionsCoronavirus Nucleocapsid ProteinsCOVID-19FemaleFisheriesGenome, ViralHumansImmunoglobulin GIncidenceMaleNucleocapsid ProteinsPandemicsAntibodies, NeutralizingAntibodies, ViralCoronavirus Nucleocapsid ProteinsImmunoglobulin Gnucleocapsid phosphoprotein, SARS-CoV-2Nucleocapsid ProteinsPhosphoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2attack rateboatcorrelatesCOVID-19fishingneutralizing antibodiesprotectionSARS-CoV-2vessel

Identifiers

PMID32826322
PMCPMC7587101
OpenAlexW3080581616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.