Evidence map›Paper›PMID 32826318›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

γ-Tocotrienol-Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs.

Sang-Gyu Lee, Teja Muralidhar Kalidindi, Hanzhi Lou, Kishore Gangangari, Blesida Punzalan, Ariana Bitton, Casey J Lee, Hebert A Vargas, Soobin Park, Lisa Bodei and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Sang-Gyu LeeDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Teja Muralidhar KalidindiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Hanzhi LouMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Kishore GangangariDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Blesida PunzalanDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ariana BittonNew York University, New York, New York.
Casey J LeeNew York University, New York, New York.
Hebert A VargasDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Soobin ParkHunter College, New York, New York.
Lisa BodeiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Michael G KharasMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Vijay K SinghDepartment of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Naga Vara Kishore PillarsettyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Steven M LarsonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York larsons@mskcc.org.
Memorial Sloan Kettering Cancer Center · USNew York University · USCity University of New York · USCornell University · USHunter College · USUniformed Services University of the Health Sciences · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Tumor Evolution and Changes in MetabolismP50CA086438 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI LARSON, STEVEN MARK · 2000 to 2015
$29.9M
Uncovering the role for MSI2 network in hematopoietic stem cellsR01DK101989 · NIDDK · SLOAN-KETTERING INST CAN RESEARCH · PI Michael Kharas, Vijay Ganesh Sankaran · 2014 to 2026
$6.2M
124I-NaI PET: Building block for precision medicine in metastatic thyroid cancerR01CA201250 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI HUMM, JOHN L, LARSON, STEVEN MARK · 2016 to 2020
$3.5M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA086438NCI NIH HHS R01 CA201250NIDDK NIH HHS R01 DK101989
6 · The paper itself

Abstract

With the successful development and increased use of targeted radionuclide therapy for treating cancer comes the increased risk of radiation injury to bone marrow-both direct suppression and stochastic effects, leading to neoplasia. Herein, we report a novel radioprotector drug, a liposomal formulation of γ-tocotrienol (GT3), or GT3-Nano for short, to mitigate bone marrow radiation damage during targeted radionuclide therapy.

Indexed as

AnimalsChromansHematopoiesisLiposomesMiceRadiation-Protective AgentsRadiotherapyTissue DistributionVitamin EChromansLiposomesplastochromanol 8Radiation-Protective AgentsVitamin Ebone marrowliposomeradiation protectionγ-tocotrienol

Identifiers

PMID32826318
PMCPMC8049360
OpenAlexW3080999168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.