ReviewReproductive biomedicine online2020
Testicular pain as an unusual presentation of COVID-19: a brief review of SARS-CoV-2 and the testis.
Review in Reproductive biomedicine online, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Effect of SARS-CoV-2 on semen parameters: A meta-analysis of 39 articles from 15 countries.Journal of global health · 2024Pooled it
- Pooled it
- A Systematic Review of Abdominal Imaging Findings in COVID-19 Patients.Visceral medicine · 2021Pooled it
- SARS-CoV-2 infection affects the lower urinary tract and male genital system: A systematic review.Journal of medical virology · 2021Pooled it
- Effect of COVID-19 on Male Reproductive System - A Systematic Review.Frontiers in endocrinology · 2021Pooled it
- Urological complications of COVID-19: a systematic review.International braz j urol : official journal of the Brazilian Society of UrologyPooled it
- SARS-CoV-2 infection reduces the number of spermatogonial stem cells and dysregulates the transcriptional landscape of the human testis.Research square · 2026Article
- Chronic scrotal content pain and viral orchiepididymitis: an overlooked hypothesis linking infection and Wallerian degeneration.Basic and clinical andrology · 2026Review
- Has the Number of Pediatric Testicular Torsion Cases Abated After the Height of the COVID-19 Pandemic?Cureus · 2026Article
- Aggravation of lower urinary tract symptoms in patients with benign prostatic hyperplasia after COVID-19.Northern clinics of Istanbul · 2025Article
- Hormonal Implications of SARS-CoV-2: A Review of Endocrine Disruptions.Scientifica · 2025Review
- CD147 mediates S protein pseudovirus of SARS-CoV-2 infection and its induction of spermatogonia apoptosis.Endocrine · 2024Article
- Preclinical Evaluation and Pilot Clinical Study ofACS pharmacology & translational science · 2024Article
- Causal associations between severe COVID-19 and diseases of seven organs: a proteome-wide mendelian randomization study.Frontiers in genetics · 2024Article
- SARS-CoV-2 and male infertility: from short- to long-term impacts.Journal of endocrinological investigation · 2023Review
- Viruses, bacteria and parasites: infection of the male genital tract and fertility.Basic and clinical andrology · 2023Review
- Male Reproductive Tract Involvement and Sperm Parameters in SARS-CoV-2 Patients: A Systematic Review and Meta-Analysis.The world journal of men's health · 2023Article
- Acute testicular infarction in the setting of SARS-CoV-2 infection and diabetic vasculopathy.Urology case reports · 2023Article
- Long COVID and hypertension-related disorders: a report from the Japanese Society of Hypertension Project Team on COVID-19.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Updates in the pathophysiology of COVID-19 infection in male reproductive and sexual health: a literature review.Frontiers in endocrinology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
research questionCan the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus induce testis damage and dysfunction?
designThis is the description of the case of a young man presenting with heavy testicular pain as the first symptom of COVID-19 infection. A review of the literature is also presented.
resultsSARS-CoV-2 may enter into the host cell by binding to angiotensin-converting enzyme 2. This receptor seems to be widely expressed in different testicular cell types, making possible the occurrence of orchitis in male patients with COVID-19 infection. From a review of the literature, it seems that there is currently no evidence of sexual transmission of SARS-CoV-2; however, the possibility of virus-induced testis damage and dysfunction cannot be excluded.
conclusionsFurther studies are necessary on the pathological effect of SARS-CoV-2 in the male reproductive system and to ensure a proper andrological follow-up for male patients.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.