ReviewPathology, research and practice2020
Can COVID 2019 induce a specific cardiovascular damage or it exacerbates pre-existing cardiovascular diseases?
Review in Pathology, research and practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Baseline and 24-Hour Changes in the Frontal QRS-T Angle During Non-Invasive Ventilation and Their Association with Clinical Outcomes in Acute Hypercapnic Respiratory Failure.Journal of clinical medicine · 2026Article
- Myocardial and Vascular Involvement in COVID-19 and Post-Vaccination States: Understanding Injury Pathways and Clinical Implications.Life (Basel, Switzerland) · 2026Review
- SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System.Neuroscience insights · 2023Article
- Biological and Exploitable Crossroads for the Immune Response in Cancer and COVID-19.Biomedicines · 2022Review
- Temporal Association Between the COVID-19 Ad26.COV2.S Vaccine and Acute Myocarditis: A Case Report and Literature Review.Cardiovascular revascularization medicine : including molecular interventions · 2022Review
- Myopericarditis After mRNA COVID-19 Vaccine in a Patient With Recent History of COVID-19.Cureus · 2022Article
- Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era-An Appraisal: Do the Pro-Health Claims Measure Up?Molecules (Basel, Switzerland) · 2022Review
- Immunopathological changes, complications, sequelae and immunological memory in COVID-19 patients.Heliyon · 2022Review
- Prevention of Cardiovascular Burden in COVID-19 Patients Suffering from Familial Hypercholesterolemia: A Global Challenge.Cardiology and therapy · 2022Article
- Presentation and Outcome of Congenital Heart Disease During Covid-19 Pandemic: A Review.Current problems in cardiology · 2022Review
- Machine Learning to Calculate Heparin Dose in COVID-19 Patients with Active Cancer.Journal of clinical medicine · 2021Article
- SARS-CoV-2 and the Eyes: A Review of the Literature on Transmission, Detection, and Ocular Manifestations.Medical science monitor : international medical journal of experimental and clinical research · 2021Review
- Coronavirus disease 2019 morbid pulmonary pathology: What did we learn from autopsy examinations?Journal of clinical and translational research · 2021Review
- Pathophysiology of infection with SARS-CoV-2-What is known and what remains a mystery.Respirology (Carlton, Vic.) · 2021Review
- Implications of the COVID-19 Pandemic for Cardiovascular Disease and Risk-Factor Management.The Canadian journal of cardiology · 2021Review
- Electrocution Stigmas in Organ Damage: The Pathological Marks.Diagnostics (Basel, Switzerland) · 2021Review
- Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective.International journal of environmental research and public health · 2021Review
- Direct or indirect endothelial damage? An unresolved question.EBioMedicine · 2021Article
- COVID-19 and the second wave during autumn: preventive strategies in cardiac and thoracic surgery divisions.European surgery : ACA : Acta chirurgica Austriaca · 2021Article
- Epigenetic susceptibility to severe respiratory viral infections and its therapeutic implications: a narrative review.British journal of anaesthesia · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel coronavirus SARS-CoV-2 causes acute respiratory distress syndrome (ARDS) with cardiovascular and multiple organ failure till death. The main mechanisms of virus internalization and interaction with the host are down-regulation or upregulation of the ACE2 receptor, the surface glycoprotein competition mechanism for the binding of porphyrin to iron in heme formation as well as interference with the immune system. The interference on renin-angiotensin-aldosterone system (RAAS) activation, heme formation, and the immune response is responsible for infection diffusion, endothelial dysfunction, vasoconstriction, oxidative damage and releasing of inflammatory mediators. The main pathological findings are bilateral interstitial pneumonia with diffuse alveolar damage (DAD). Because ACE receptor is also present in the endothelium of other districts as well as in different cell types, and as porphyrins are transporters in the blood and other biological liquids of iron forming heme, which is important in the assembly of the hemoglobin, myoglobin and the cytochromes, multiorgan damage occurs both primitive and secondary to lung damage. More relevantly, myocarditis, acute myocardial infarction, thromboembolism, and disseminated intravasal coagulation (DIC) are described as complications in patients with poor outcome. Here, we investigated the role of SARSCoV-2 on the cardiovascular system and in patients with cardiovascular comorbidities, and possible drug interference on the heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.