ArticleReproductive biology and endocrinology : RB&E2020
Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study.
Article in Reproductive biology and endocrinology : RB&E, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Impact of endometrial thickness on reproductive outcome in fresh and frozen-thawed embryo transfer: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Pooled it
- Vasodilators for women undergoing fertility treatment.The Cochrane database of systematic reviews · 2025Pooled it
- The Effect of Endometrial Thickness on Pregnancy, Maternal, and Perinatal Outcomes of Women in Fresh Cycles After IVF/ICSI: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Comparison of the efficacy of single vs. double autologous platelet-rich plasma intrauterine infusion on endometrial receptivity in thin endometrium patients: a prospective randomized controlled trial.Frontiers in endocrinology · 2025Trial
- Definition of thin endometrium from the perspective of miscarriage following frozen embryo transfer: a retrospective cohort study of 15,979 pregnancies.BMC pregnancy and childbirth · 2026Article
- Embryological and clinical predictors of implantation and live birth in 3000 single euploid embryo transfer cycles: a retrospective cohort study.Archives of gynecology and obstetrics · 2026Article
- Antibiotic Exposure and Early Reproductive Outcomes of In Vitro Fertilization (IVF) in a Chinese Couple-Based Preconception Cohort.Environment & health (Washington, D.C.) · 2026Article
- Association between endometrial thickness and cumulative live birth rate in one oocyte-retrieval cycle: a retrospective cohort study including 26,127 patients.BMC pregnancy and childbirth · 2026Article
- Subendometrial platelet-rich plasma injection for refractory thin endometrium: a prospective pilot study.Scientific reports · 2026Article
- The impact of the interaction between ovarian markers and the endometrium on the outcomes of assisted reproduction.Frontiers in cell and developmental biology · 2026Article
- Linear association between endometrial thickness and live birth in single blastocyst transfers: A dual-center retrospective cohort study.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles.BMC pregnancy and childbirth · 2025Article
- Effectiveness and safety of consecutive single embryo transfer compared to double embryo transfer: results from the UK HFEA registry.Human reproduction (Oxford, England) · 2025Article
- Plasminogen activator inhibitor 1 is a novel predictor in human serum/follicular fluid for diminished ovarian reserve.BMC women's health · 2025Article
- The influence of endometrial thickness on clinical pregnancy outcomes in early-follicular long-acting and midluteal short-acting GnRH agonist long protocols: a large retrospective study.Frontiers in endocrinology · 2025Article
- Article
- A critical appraisal of studies on endometrial thickness and embryo transfer outcome.Reproductive biomedicine online · 2023Review
- Determinants of Embryo Implantation: Roles of the Endometrium and Embryo in Implantation Success.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Factors influencing clinical pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection in older women.African health sciences · 2023Article
- Nomogram for Predicting Live Birth after the First Fresh Embryo Transfer in Patients with PCOS Undergoing IVF/ICSI Treatment with the GnRH-Ant Protocol.Diagnostics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
20 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSuccessful implantation and delivery require both the functional embryo and receptive endometrium in assisted reproductive technology (ART) cycles. However, little is known about embryo-endometrial interaction on live-birth. We aimed to investigate the independent effect and interaction of endometrial thickness (EMT) and embryo quality on live-birth in fresh embryo transfer (ET) cycles.
methodsWe conducted a retrospective cohort study including 15,012 ART cycles between 2013 and 2016 in three centers in China. Poisson regression with generalized estimating equations was employed to calculate relative risks (RRs) and 95% confidence intervals (CIs). We estimated the interaction of embryo quality and EMT on live-birth rate (LBR).
resultsThe LBR per cycle was 42.8% overall. LBR increased with increasing EMT and reached a plateau (50.6 to 54.2%) when EMT was 11 mm or thicker. Embryo quality represented by cumulative score was associated with LBR independently of number of embryos transferred and EMT. LBR was not increased with thicker EMT when only Q1 cleavage-stage embryo transferred (aRR 0.95, 95%CI 0.61-1.46). LBR was not increased significantly with thicker EMT with transfer of two good-quality cleavage-stage embryos and any blastocyst combination except Q1 group. There was significant interaction between EMT and embryo quality on LBR for cleavage-stage ETs (P=0.023).
conclusionsThis study demonstrated the nonlinear EMT-LBR association and the EMT cut-off value of 11 mm which may be of more clinical significance for predicting live-birth. Embryo quality is an independent prognostic tool for LBR. Our finding of significant embryo-endometrial interaction indicates combination of EMT and embryos quality might improve the prognostic value in clinical practice for live-birth in patients undergoing transfer of 1-2 fresh cleavage-stage embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.