ArticleNutrients2020
A Clinical Tool to Predict Low Serum Selenium in Patients with Worsening Heart Failure.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Selenium nutritional status and cardiovascular diseases: mechanisms of cardioprotection and 21 years of global research trends in precision prevention (2005-2026).Frontiers in nutrition · 2026Pooled it
- Redox Modulation of Erythropoiesis by Selenoproteins.Biological trace element research · 2026Review
- Cadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination survey.Diabetology & metabolic syndrome · 2025Article
- Exploring the relationship between vitamin B12, methylmalonic acid levels and all-cause mortality in heart failure populations: insights from the NHANES database.Frontiers in nutrition · 2025Article
- Micronutrient deficiencies and new-onset atrial fibrillation in a community-based cohort: data from PREVEND.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Observational
- Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients.ESC heart failure · 2024Article
- Molecular Linkage between Immune System Disorders and Atherosclerosis.Current issues in molecular biology · 2023Review
- The Role of Selenium in Atherosclerosis Development, Progression, Prevention and Treatment.Biomedicines · 2023Review
- Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?Journal of internal medicine · 2022Review
- High selenium levels associate with reduced risk of mortality and new-onset heart failure: data from PREVEND.European journal of heart failure · 2022Article
- Article
- Dilated Left Ventricular End-Diastolic Diameter Is a New Risk Factor of Acute Kidney Injury Following Coronary Angiography.Frontiers in cardiovascular medicine · 2022Article
- Selenoprotein DIO2 Is a Regulator of Mitochondrial Function, Morphology and UPRmt in Human Cardiomyocytes.International journal of molecular sciences · 2021Article
- The Impact of Selenium Deficiency on Cardiovascular Function.International journal of molecular sciences · 2021Review
- Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective.Current heart failure reports · 2021Review
- Se Status Prediction by Food Intake as Compared to Circulating Biomarkers in a West Algerian Population.Nutrients · 2020Observational
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Selenium is an essential micronutrient, and a low selenium concentration (<100 µg/L) is associated with a poorer quality of life and exercise capacity, and an impaired prognosis in patients with worsening heart failure. Measuring selenium concentrations routinely is laborious and costly, and although its clinical utility is yet to be proven, an easy implemented model to predict selenium status is desirable. A stepwise multivariable logistic regression analysis was performed using routinely measured clinical factors. Low selenium was independently predicted by: older age, lower serum albumin, higher N-terminal pro-B-type natriuretic peptide levels, worse kidney function, and the presence of orthopnea and iron deficiency. A 10-points risk-model was developed, and a score of ≥6 points identified >80% of patients with low selenium (sensitivity of 44%, specificity of 80%). Given that selenium and iron overlap in their physiological roles, we evaluated the shared determinants and prognostic associates. Both deficiencies shared similar clinical characteristics, including the model risk factors and, in addition, a low protein intake and high levels of C-reactive protein. Low selenium was associated with a similar or worse prognosis compared to iron deficiency. In conclusion, although it is difficult to exclude low selenium based on clinical characteristics alone, we provide a prediction tool which identifies heart failure patients at higher risk of having a low selenium status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.