Evidence map›Paper›PMID 32825727›Full record

ArticleCancers2020

Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer.

Koji Matsuo, Kazuhiro Tanabe, Masaru Hayashi, Masae Ikeda, Miwa Yasaka, Hiroko Machida, Masako Shida, Kenji Sato, Hiroshi Yoshida, Takeshi Hirasawa and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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  7. Metabolomics analysis of MnORSC advances · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Koji MatsuoDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-6232-8701
Kazuhiro TanabeMedical Solution Promotion Department, LSI Medience Corporation, Tokyo 1748555, Japan.
Masaru HayashiDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan.
Masae IkedaDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan.ORCID 0000-0002-7289-4379
Miwa YasakaDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan.
Hiroko MachidaDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan.ORCID 0000-0003-2252-3577
Masako ShidaDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan.
Kenji SatoDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan.
Hiroshi YoshidaDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan.
Takeshi HirasawaDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan.ORCID 0000-0002-4009-1758
Tadashi ImanishiDepartment of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa 2591193, Japan.ORCID 0000-0002-1182-9127
Mikio MikamiDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan.ORCID 0000-0002-7496-3518
Tokai University · JPUniversity of Southern California · US

Funding

AMED 20lm0203004j0003Ensign Endowment for Gynecologic Cancer Research -Ministry of Education, Culture, Sports, Science and Technology 17H04340;18K09274; and 18K09300
6 · The paper itself

Abstract

Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis protein 4 (HE4) for detecting early stage epithelial ovarian cancer. Combined CSGSA, CA125, and HE4 had improved diagnostic performance. Thus, CSGSA may be a useful screening tool for detecting early stage epithelial ovarian cancer.

Indexed as

cancer antigen 125comprehensive serum glycopeptide spectra analysisepithelial ovarian cancerhuman epididymis protein 4orthogonal partial least-squares discriminant analysisscreening

Identifiers

PMID32825727
PMCPMC7563232
OpenAlexW3081018594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.