Evidence map›Paper›PMID 32825667›Full record

ReviewInternational journal of molecular sciences2020

Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers.

Lyna Kara-Terki, Lucas Treps, Christophe Blanquart, Delphine Fradin

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Lyna Kara-TerkiCRCINA, INSERM, Université de Nantes, F-44000 Nantes, France.
Lucas TrepsCRCINA, INSERM, Université de Nantes, F-44000 Nantes, France.ORCID 0000-0003-0735-9000
Christophe BlanquartCRCINA, INSERM, Université de Nantes, F-44000 Nantes, France.ORCID 0000-0002-0917-3747
Delphine FradinCRCINA, INSERM, Université de Nantes, F-44000 Nantes, France.ORCID 0000-0001-6231-2649
Inserm · FR

Funding

Cancéropole Grand Ouest ExomiRLigue Contre le Cancer 2020
6 · The paper itself

Abstract

Extracellular vesicles (EVs), such as exosomes, are critical mediators of intercellular communication between tumor cells and other cells located in the microenvironment but also in more distant sites. Exosomes are small EVs that can carry a variety of molecules, such as lipids, proteins, and non-coding RNA, especially microRNAs (miRNAs). In thoracic cancers, including lung cancers and malignant pleural mesothelioma, EVs contribute to the immune-suppressive tumor microenvironment and to tumor growth and metastasis. In this review, we discuss the recent understanding of how exosomes behave in thoracic cancers and how and why they are promising liquid biomarkers for diagnosis, prognosis, and therapy, with a special focus on exosomal miRNAs.

Indexed as

Tumor MicroenvironmentBiomarkers, TumorClinical Trials as TopicExtracellular VesiclesGene Expression Regulation, NeoplasticHumansLung NeoplasmsMicroRNAsPrognosisThoracic NeoplasmsBiomarkers, TumorMicroRNAsexosomelung cancermesotheliomamiRNA

Identifiers

PMID32825667
PMCPMC7504491
OpenAlexW3080290654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.