Evidence map›Paper›PMID 32825590›Full record

ArticleMolecules (Basel, Switzerland)2020

DDAO Controlled Synthesis of Organo-Modified Silica Nanoparticles with Encapsulated Fluorescent Boron Dipyrrins and Study of Their Uptake by Cancerous Cells.

Aleksandr A Goncharenko, Ilya A Tarasyuk, Yuriy S Marfin, Kirill V Grzhegorzhevskii, Albert R Muslimov, Andrey B Bondarenko, Maxim D Lebedev, Ilya A Kuz'min, Artur S Vashurin, Kirill V Lepik and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Aleksandr A GoncharenkoDepartment of Biophysics, Polytechnicheskaya, Peter The Great St. Petersburg Polytechnic University, 29, 195251 St. Petersburg, Russia.
Ilya A TarasyukIvanovo State University of Chemistry and Technology, Sheremetevsky str., 7, 153000 Ivanovo, Russia.
Yuriy S MarfinIvanovo State University of Chemistry and Technology, Sheremetevsky str., 7, 153000 Ivanovo, Russia.
Kirill V GrzhegorzhevskiiInstitute of Natural Sciences and Mathematics, Ural Federal University, 19, 620002 Mira St. Ekaterinburg, Russia.
Albert R MuslimovRM Gorbacheva Research Institute of Pediatric Oncology, Hematology and Transplantation, Pavlov University, Lva Tolstogo 6/8, 197022 St. Petersburg, Russia.
Andrey B BondarenkoSt. Petersburg State University, 7/9 Universitetskaya nab., 199034 Saint-Petersburg, Russia.
Maxim D LebedevIvanovo State University of Chemistry and Technology, Sheremetevsky str., 7, 153000 Ivanovo, Russia.
Ilya A Kuz'minIvanovo State University of Chemistry and Technology, Sheremetevsky str., 7, 153000 Ivanovo, Russia.
Artur S VashurinIvanovo State University of Chemistry and Technology, Sheremetevsky str., 7, 153000 Ivanovo, Russia.ORCID 0000-0003-2239-8753
Kirill V LepikRM Gorbacheva Research Institute of Pediatric Oncology, Hematology and Transplantation, Pavlov University, Lva Tolstogo 6/8, 197022 St. Petersburg, Russia.
Alexander S TiminDepartment of Biophysics, Polytechnicheskaya, Peter The Great St. Petersburg Polytechnic University, 29, 195251 St. Petersburg, Russia.ORCID 0000-0002-0276-7892
Evgeniy V RumyantsevIvanovo State University of Chemistry and Technology, Sheremetevsky str., 7, 153000 Ivanovo, Russia.
Ivanovo State University of Chemistry and Technology · RUFirst Pavlov State Medical University of St. Petersburg · RUNational Research Tomsk State University · RUPeter the Great St. Petersburg Polytechnic University · RUSt Petersburg University · RUUral Federal University · RU

Funding

Council on grants of the President of the Russian Federation МК-1098.2019.3Russian Foundation for Basic Research 18-33-20218Russian Foundation for Basic Research 19-33-90190
6 · The paper itself

Abstract

The design of cargo carriers with high biocompatibility, unique morphological characteristics, and capability of strong bonding of fluorescent dye is highly important for the development of a platform for smart imaging and diagnostics. In this paper, BODIPY-doped silica nanoparticles were prepared through a "one-pot" soft-template method using a sol-gel process. Several sol-gel precursors have been used in sol-gel synthesis in the presence of soft-template to obtain the silica-based materials with the most appropriate morphological features for the immobilization of BODIPY molecules. Obtained silica particles have been shown to be non-cytotoxic and can be effectively internalized into the cervical cancer cell line (HeLa). The described method of synthesis allows us to obtain silica-based carriers with an immobilized fluorescent dye that provide the possibility for real-time imaging and detection of these carriers.

Indexed as

BoronBoron CompoundsCell SurvivalDimethylaminesFemaleHeLa CellsHumansNanoparticlesPhase TransitionSilicon DioxideUterine Cervical Neoplasms4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoronBoron CompoundsDimethylaminesdodecyldimethylamine oxideSilicon DioxideBODIPYoil-in-waterone-pot synthesissilica nanoparticlessoft-template

Identifiers

PMID32825590
PMCPMC7504138
OpenAlexW3080582093

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.