Evidence map›Paper›PMID 32825588›Full record

ArticleCancers2020

TILs Immunophenotype in Breast Cancer Predicts Local Failure and Overall Survival: Analysis in a Large Radiotherapy Trial with Long-Term Follow-Up.

Ewan Millar, Lois Browne, Iveta Slapetova, Fei Shang, Yuqi Ren, Rachel Bradshaw, Heather Ann Brauer, Sandra O'Toole, Julia Beretov, Renee Whan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  5. Spatial proximity of CD8NPJ breast cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Ewan MillarDepartment of Anatomical Pathology, NSW Health Pathology, St George Hospital, Kogarah, NSW 2217, Australia.ORCID 0000-0002-9778-3253
Lois BrowneCancer Care Centre, St George Hospital, Kogarah, NSW 2217, Australia.
Iveta SlapetovaBiomedical Imaging Facility, Mark Wainwright Analytical Centre, University of New South Wales Sydney, Kensington, NSW 2052, Australia.
Fei ShangBiomedical Imaging Facility, Mark Wainwright Analytical Centre, University of New South Wales Sydney, Kensington, NSW 2052, Australia.
Yuqi RenNanoString Technologies Inc., Seattle, WA 98109, USA.
Rachel BradshawNanoString Technologies Inc., Seattle, WA 98109, USA.
Heather Ann BrauerNanoString Technologies Inc., Seattle, WA 98109, USA.
Sandra O'TooleDepartment of Anatomical Pathology, NSW Health Pathology, Royal Prince Alfred Hospital, Camperdown, NSW 2217, Australia.
Julia BeretovDepartment of Anatomical Pathology, NSW Health Pathology, St George Hospital, Kogarah, NSW 2217, Australia.
Renee WhanBiomedical Imaging Facility, Mark Wainwright Analytical Centre, University of New South Wales Sydney, Kensington, NSW 2052, Australia.
Peter H GrahamFaculty of Medicine, St George & Sutherland Clinical School, University of New South Wales Sydney, Kensington, NSW 2052, Australia.
Nanostring Technologies (United States) · USUNSW Sydney · AUSutherland Hospital · AUCamden and Campbelltown Hospitals · AUSt George Hospital · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine the prognostic significance of the immunophenotype of tumour-infiltrating lymphocytes (TILs) within a cohort of breast cancer patients with long-term follow-up.

methodsMultiplexed immunofluorescence and automated image analysis were used to assess the expression of CD3, CD8, CD20, CD68, Fox P3, PD-1 and PD-L1 in a clinical trial of local excision and radiotherapy randomised to a cavity boost or not (

resultsLR was predicted by low CD8 in MVA in the whole cohort (HR 2.34, CI 1.4-4.02,

conclusionsImmunophenotype adds further prognostic data to help further stratify risk of LR and OS even in TILs low-luminal tumours.

Indexed as

breast cancerimmunophenotypeprognosistumour infiltrating lymphocytes (TILs)

Identifiers

PMID32825588
PMCPMC7563743
OpenAlexW3080406741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.