Evidence map›Paper›PMID 32825529›Full record

ArticlePathogens (Basel, Switzerland)2020

Evaluation of Nucleoside Analogs as Antimicrobials Targeting Unique Enzymes in

Monideep Chakraborti, Samantha Schlachter, Shekerah Primus, Julie Wagner, Brandi Sweet, Zoey Carr, Kenneth A Cornell, Nikhat Parveen

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Current and emerging approaches for eliminatingFrontiers in microbiology · 2024
    Review
  3. Article
  4. Article
  5. Pathway Driven Target Selection inFrontiers in cellular and infection microbiology · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Monideep ChakrabortiDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Samantha SchlachterDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Shekerah PrimusDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Julie WagnerDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID 83725, USA.
Brandi SweetDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID 83725, USA.ORCID 0000-0002-6375-4147
Zoey CarrDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID 83725, USA.ORCID 0000-0002-7622-7725
Kenneth A CornellDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID 83725, USA.
Nikhat ParveenDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0000-0003-0592-0693
Boise State University · USRutgers, The State University of New Jersey · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Carolyn Hovde Bohach · 2012 to 2026
$59.8M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OXFORD, JULIA THOM · 2014 to 2023
$22.7M
Interactions of tick-borne pathogens, Borrelia burgdorferi and Babesia microti with the mammalian host using rodent model of co-infectionsR01AI137425 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PARVEEN, NIKHAT · 2019 to 2022
$1.6M
The Southwest Idaho Bridges to the BaccalaureateR25GM123927 · NIGMS · BOISE STATE UNIVERSITY · PI JORCYK, CHERYL LYNN, LYSNE, STEVEN · 2017 to 2021
$1.6M
Development of Novel Antibiotics to Treat Protozoan ParasitesR15GM125065 · NIGMS · BOISE STATE UNIVERSITY · PI CORNELL, KENNETH A · 2017 to 2017
$418k
NIAID NIH HHS R01 AI137425NIGMS NIH HHS P20 GM103408NIGMS NIH HHS P20 GM109095NIGMS NIH HHS R25GM123927.NIH HHS P20GM103408NIH HHS P20GM109095NIH HHS R01AI148214NIH HHS R15GM125065
6 · The paper itself

Abstract

The first line therapy for Lyme disease is treatment with doxycycline, amoxicillin, or cefuroxime. In endemic regions, the persistence of symptoms in many patients after completion of antibiotic treatment remains a major healthcare concern. The causative agent of Lyme disease is a spirochete,

Indexed as

antimicrobialsBgpBorrelia burgdorferimethylthioadenosine/S-adenosylhomocysteine nucleosidaseMTANPfs

Identifiers

PMID32825529
PMCPMC7557402
OpenAlexW3073336838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.