Evidence map›Paper›PMID 32825453›Full record

ArticleInternational journal of molecular sciences2020

Role of CGRP in Neuroimmune Interaction via NF-κB Signaling Genes in Glial Cells of Trigeminal Ganglia.

Shaista Afroz, Rieko Arakaki, Takuma Iwasa, Arief Waskitho, Masamitsu Oshima, Yoshizo Matsuka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Shaista AfrozDepartment of Prosthodontics and Dental Material, ZA Dental College, Aligarh Muslim University, Aligarh 202002, India.
Rieko ArakakiDepartment of Oral Molecular Pathology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 700-8504, Japan.
Takuma IwasaDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 700-8504, Japan.
Arief WaskithoDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 700-8504, Japan.
Masamitsu OshimaDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 700-8504, Japan.
Yoshizo MatsukaDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 700-8504, Japan.ORCID 0000-0003-1069-2605
Tokushima University · JPAligarh Muslim University · IN

Funding

Ministry of Education, Culture, Sports, Science and Technology 18H02992
6 · The paper itself

Abstract

Activation of the trigeminal system causes the release of various neuropeptides, cytokines, and other immune mediators. Calcitonin gene-related peptide (CGRP), which is a potent algogenic mediator, is expressed in the peripheral sensory neurons of trigeminal ganglion (TG). It affects the inflammatory responses and pain sensitivity by modulating the activity of glial cells. The primary aim of this study was to use array analysis to investigate the effect of CGRP on the glial cells of TG in regulating nuclear factor kappa B (NF-κB) signaling genes and to further check if CGRP in the TG can affect neuron-glia activation in the spinal trigeminal nucleus caudalis. The glial cells of TG were stimulated with CGRP or Minocycline (Min) + CGRP. The effect on various genes involved in NF-κB signaling pathway was analyzed compared to no treatment control condition using a PCR array analysis. CGRP, Min + CGRP or saline was directly injected inside the TG and the effect on gene expression of

Indexed as

AnimalsCalcitonin Gene-Related PeptideCaspase 3Early Growth Response Protein 1Gene Expression RegulationMaleMinocyclineMyeloid Differentiation Factor 88NeurogliaNF-kappa BProto-Oncogene Proteins c-aktRats, Sprague-DawleySignal TransductionTrigeminal Caudal NucleusTrigeminal GanglionAkt1 protein, ratCalcitonin Gene-Related PeptideCasp3 protein, ratCaspase 3Early Growth Response Protein 1Egr1 protein, ratMinocyclineMyd88 protein, ratMyeloid Differentiation Factor 88NF-kappa BProto-Oncogene Proteins c-aktcalcitonin gene related peptide (CGRP)glial cellsnuclear factor kappa B (NF-κB)satellite glial cellstrigeminal ganglion

Identifiers

PMID32825453
PMCPMC7503816
OpenAlexW3078178058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.