Evidence map›Paper›PMID 32825435›Full record

ArticleInternational journal of molecular sciences2020

Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity.

Linda Feldbrügge, Katrin Splith, Ines Kämmerer, Sandra Richter, Anna Riddermann, Santiago Andres Ortiz Galindo, Felix Krenzien, Tobias Müller, Eva Csizmadia, Johann Pratschke and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. GLP-1-Mediated Pregnancy and Neonatal Complications in Mice.Journal of developmental biology · 2025
    Article
  3. Review
  4. Dissecting the Purinergic Signaling Puzzle.International journal of molecular sciences · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Linda FeldbrüggeDepartment of Surgery, Campus Charité Mitte and Campus Virchow Klinikum, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Katrin SplithDepartment of Surgery, Campus Charité Mitte and Campus Virchow Klinikum, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Ines KämmererTranslational Centre for Regenerative Medicine (TRM), Universität Leipzig, 04103 Leipzig, Germany.
Sandra RichterDepartment of Surgery, Campus Charité Mitte and Campus Virchow Klinikum, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Anna RiddermannDepartment of Surgery, Campus Charité Mitte and Campus Virchow Klinikum, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Santiago Andres Ortiz GalindoDepartment of Surgery, Campus Charité Mitte and Campus Virchow Klinikum, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Felix KrenzienDepartment of Surgery, Campus Charité Mitte and Campus Virchow Klinikum, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.ORCID 0000-0003-0593-9917
Tobias MüllerDivision of Hepatology and Gastroenterology, Medical Department, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Eva CsizmadiaDepartments of Medicine and Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard University, Boston, MA 02215, USA.
Johann PratschkeDepartment of Surgery, Campus Charité Mitte and Campus Virchow Klinikum, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Simon C RobsonDepartments of Medicine and Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard University, Boston, MA 02215, USA.
Moritz SchmelzleDepartment of Surgery, Campus Charité Mitte and Campus Virchow Klinikum, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Humboldt-Universität zu Berlin · DEBeth Israel Deaconess Medical Center · USLeipzig University · DE

Funding

Therapeutic assessment of synthetic heparin sulfates in transplantation modelsP01HL107152 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI DESAI, UMESH RAMANLAL · 2011 to 2017
$15.8M
Engineering Inhibitory Antibodies to Ectoenzymes for Cancer TreatmentR21CA164970 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROBSON, SIMON C. · 2012 to 2013
$405k
Bundesministerium für Bildung und Forschung PtJ-Bio 0315883Deutsche Forschungsgemeinschaft FE1434/2-1Deutsche Forschungsgemeinschaft SCHM2661/3-1Deutsche Forschungsgemeinschaft SCHM2661/3-2NIH HHS P01HL107152NIH HHS R21CA164970
6 · The paper itself

Abstract

Ecto-nucleotidase triphosphate diphosphohydrolase-2 (NTPDase2) is an ecto-enzyme that is expressed on portal fibroblasts in the liver that modulates P2 receptor signaling by regulating local concentrations of extracellular ATP and ADP. NTPDase2 has protective properties in liver fibrosis and may impact bile duct epithelial turnover. Here, we study the role of NTPDase2 in acute liver injury using an experimental model of acetaminophen (APAP) intoxication in mice with global deletion of NTPDase2. Acute liver toxicity was caused by administration of acetaminophen in wild type (WT) and NTPDase2-deficient (

Indexed as

AcetaminophenAdenosine TriphosphatasesAlanine TransaminaseAlkaline PhosphataseAnimalsChemical and Drug Induced Liver InjuryFibroblastsGene Expression Regulation, EnzymologicInterleukin-6LiverLiver RegenerationLymphokinesMaleMice, Inbred C57BLMice, Mutant StrainsNecrosisAcetaminophenAdenosine TriphosphatasesAlanine TransaminaseAlkaline PhosphataseectoATPaseInterleukin-6interleukin-6, mouseLymphokinesPdgfd protein, mousePlatelet-Derived Growth FactorTumor Necrosis Factor-alphaAPAP hepatotoxicityEntpd2NTPDase2purinergic signaling

Identifiers

PMID32825435
PMCPMC7504458
OpenAlexW3075425989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.