Evidence map›Paper›PMID 32825400›Full record

SynthesisNutrients2020

Nutritional Interventions in the Management of Fibromyalgia Syndrome.

Giuditta Pagliai, Ilaria Giangrandi, Monica Dinu, Francesco Sofi, Barbara Colombini

2 registry-linked trialsOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07403929 narecruitingnot on this mapstarted 2026, after this paper: background citation

Determination of the Effect of Fermented Grape Juice Consumption on Oxidative Stress and Inflammation Biomarkers and SIRT-1 Levels in Fibromyalgia Patients

TypeinterventionalSponsorHacettepe UniversityRan2026 to 2027Enrolled45ConditionsFibromyalgia, Fibromyalgia (FM), Fibromyalgia Syndrome, PrimaryArmsMedical Nutrition Therapy (MNT), Hardaliye (200 mL/day)
NCT07782255 nacompletednot on this mapstarted 2025, after this paper: background citation

Interdisciplinary Therapeutic Intervention for People With Persistent Pain

TypeinterventionalSponsorPlaya Ancha UniversityRan2025 to 2025Enrolled15ConditionsFybromyalgiaArmsMultimodal Interdisciplinary Therapeutic Intervention
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Efficacy and safety of weekly vitamin DClinical rheumatology · 2021
    Trial
  8. The Effect of Multiprobiotics on Memory and Attention in Fibromyalgia: A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2021
    Trial
  9. Review
  10. "Food as Friend or Enemy": A Qualitative Study of Motivations Underlying Restrictive Dietary Practices in Fibromyalgia.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Giuditta PagliaiDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Ilaria GiangrandiDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Monica DinuDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Francesco SofiDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0001-7113-7424
Barbara ColombiniDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0003-1397-9791
Azienda Ospedaliero-Universitaria Careggi · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibromyalgia (FM) is a multifactorial syndrome of unknown etiology, characterized by widespread chronic pain and various somatic and psychological manifestations. The management of FM requires a multidisciplinary approach combining both pharmacological and nonpharmacological strategies. Among nonpharmacological strategies, growing evidence suggests a potential beneficial role for nutrition. This review summarizes the possible relationship between FM and nutrition, exploring the available evidence on the effect of dietary supplements and dietary interventions in these patients. Analysis of the literature has shown that the role of dietary supplements remains controversial, although clinical trials with vitamin D, magnesium, iron and probiotics' supplementation show promising results. With regard to dietary interventions, the administration of olive oil, the replacement diet with ancient grains, low-calorie diets, the low FODMAPs diet, the gluten-free diet, the monosodium glutamate and aspartame-free diet, vegetarian diets as well as the Mediterranean diet all appear to be effective in reducing the FM symptoms. These results may suggest that weight loss, together with the psychosomatic component of the disease, should be taken into account. Therefore, although dietary aspects appear to be a promising complementary approach to the treatment of FM, further research is needed to provide the most effective strategies for the management of FM.

Indexed as

AcetylcarnitineAscorbic AcidChlorellaDietary SupplementsDiet, VeganFibromyalgiaNutritional Physiological PhenomenaNutrition TherapySyndromeUbiquinoneVitamin EAcetylcarnitineAscorbic Acidcoenzyme Q10UbiquinoneVitamin Edietfibromyalgiafoodnutritionreview

Identifiers

PMID32825400
PMCPMC7551285
OpenAlexW3069445337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.