Evidence map›Paper›PMID 32825391›Full record

ReviewInternational journal of molecular sciences2020

Phage Display to Augment Biomaterial Function.

Thomas A Davidson, Samantha J McGoldrick, David H Kohn

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas A DavidsonDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Samantha J McGoldrickDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
David H KohnDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8833-0076

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Engineering anti-fragile tooth/restorative interfacesR01DE026116 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2016 to 2020
$1.4M
NIDCR NIH HHS R01 DE026116NIDCR NIH HHS T32 DE007057NIH HHS NIH R01 DE026116
6 · The paper itself

Abstract

Biomaterial design relies on controlling interactions between materials and their biological environments to modulate the functions of proteins, cells, and tissues. Phage display is a powerful tool that can be used to discover peptide sequences with high affinity for a desired target. When incorporated into biomaterial design, peptides identified via phage display can functionalize material surfaces to control the interaction between a biomaterial and its local microenvironment. A targeting peptide has high specificity for a given target, allowing for homing a specific protein, cell, tissue, or other material to a biomaterial. A functional peptide has an affinity for a given protein, cell, or tissue, but also modulates its target's activity upon binding. Biomaterials can be further enhanced using a combination of targeting and/or functional peptides to create dual-functional peptides for bridging two targets or modulating the behavior of a specific protein or cell. This review will examine current and future applications of phage display for the augmentation of biomaterials.

Indexed as

Biocompatible MaterialsAnimalsCell AdhesionCell DifferentiationCell MovementCell Surface Display TechniquesDrug Delivery SystemsHumansMolecular ImagingPeptidesTissue EngineeringBiocompatible MaterialsPeptidesbiomaterialsdual-functioning peptidespeptidesphage displaytissue engineering

Identifiers

PMID32825391
PMCPMC7504225

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.