SynthesisInternational journal of environmental research and public health2020
The Effects of Exercise on BDNF Levels in Adolescents: A Systematic Review with Meta-Analysis.
Synthesis in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 6 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Effects of exercise intervention parameters on anxiety symptoms in adolescents: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychology · 2026Pooled it
- Physical activity and two-year change in adolescent well-being in nine countries.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025Pooled it
- The impact of physical activity on working memory in children with ADHD: a meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Immediate effect of high-intensity exercise on brain-derived neurotrophic factor in healthy young adults: A systematic review and meta-analysis.Journal of sport and health science · 2022Pooled it
- The effect of physical exercise on circulating brain-derived neurotrophic factor in healthy subjects: A meta-analysis of randomized controlled trials.Brain and behavior · 2022Pooled it
- Effects of Training with Different Modes of Strength Intervention on Psychosocial Disorders in Adolescents: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Effect of high-intensity interval training on hippocampal metabolism in older adolescents.Psychophysiology · 2022Trial
- Context-dependent modulation of LTP and BDNF/TrkB signaling in the dentate gyrus following combined progressive aerobic and rotarod training in male wistar rats.IBRO neuroscience reports · 2026Article
- Effects of Exercise Interventions on Peripheral Brain-Derived Neurotrophic Factor: An Umbrella Meta-Analysis Across Clinical and Healthy Populations.Journal of clinical medicine · 2026Review
- Review
- Outline: The Long-Term Impact of Exercise on Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- Effects of Regular Exercise on Peripheral Brain-Derived Neurotrophic Factor in Neurological and Non-Neurological Populations: A Meta-Analysis with Meta-Regression.Brain sciences · 2025Review
- Comparison of Acute Irisin and Cognitive Responses to Different Exercise Modalities Among Late Adolescents.Healthcare (Basel, Switzerland) · 2025Article
- Exercise as Modulator of Brain-Derived Neurotrophic Factor in Adolescents: A Systematic Review of Randomized Controlled Trials.Sports (Basel, Switzerland) · 2025Review
- Exercise as Modulator of Brain-Derived Neurotrophic Factor (BDNF) in Children: A Systematic Review of Randomized Controlled Trials.Life (Basel, Switzerland) · 2025Review
- Effects of High-Resistance Elastic Band Training and a Curcumin-Based Formulation on Neuro-Oxidative and Functional Health in Sedentary Older Adults.Healthcare (Basel, Switzerland) · 2025Article
- Mediating effects of physical fitness index between physical activity and executive function in Chinese adolescents: an observational study.Frontiers in psychology · 2025Article
- Age-dependent mechanisms of exercise in the treatment of depression: a comprehensive review of physiological and psychological pathways.Frontiers in psychology · 2025Review
- Dietary Patterns, Serum BDNF and Fatty Acid Profiles in Physically Active Male Young Adults: A Cluster Analysis Study.Nutrients · 2024Article
- The Compelling Role of Brain-Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of BDNF Activators.CNS neuroscience & therapeutics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10-19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive effect in favor of the intervention, there were no significant differences (standardized mean difference 0.28 ng/mL, 95% confidence interval -0.28 to 0.85;
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.