ReviewNutrients2020
Influence of Iron on the Gut Microbiota in Colorectal Cancer.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Gut microbiome signatures associated with iron-deficiency anemia in young adults.Iranian journal of microbiology · 2026Article
- Processed Pearl Millet Improves the Morphology and Gut Microbiota in Wistar Rats.Foods (Basel, Switzerland) · 2025Article
- Exploring the gut microbiome's influence on cancer-associated anemia: Mechanisms, clinical challenges, and innovative therapies.World journal of gastrointestinal pharmacology and therapeutics · 2025Article
- Causal Relationships Between Iron Deficiency Anemia, Gut Microbiota, and Metabolites: Insights from Mendelian Randomization and In Vivo Data.Biomedicines · 2025Article
- The Role of Reactive Oxygen Species in Colorectal Cancer Initiation and Progression: Perspectives on Theranostic Approaches.Cancers · 2025Review
- Genomic Face-off: AnCurrent genomics · 2025Article
- Article
- Therapeutic and antioxidant potential of bionanofactory Ochrobactrum sp.-mediated magnetite and zerovalent iron nanoparticles against acute experimental toxoplasmosis.PLoS neglected tropical diseases · 2023Article
- Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice.Science China. Life sciences · 2023Article
- Preoperative Identification and Management of Anemia in the Colorectal Surgery Patient.Clinics in colon and rectal surgery · 2023Review
- Characterizing the microbiota of cleft lip and palate patients: a comprehensive review.Frontiers in cellular and infection microbiology · 2023Review
- Moxibustion attenuates liver metastasis of colorectal cancer by regulating gut microbial dysbiosis.American journal of cancer research · 2023Article
- Iron metabolism in colorectal cancer.Frontiers in oncology · 2023Review
- Association between iron supplementation and the presence of diarrhoea in Peruvian children aged 6-59 months: analysis of the database of the Demographic and Family Health Survey in Peru (DHS, Peru), years 2009-2019.Public health nutrition · 2022Article
- Biological Evaluation, Molecular Docking Analyses, and ADME Profiling of Certain New Quinazolinones as Anti-colorectal Agents.ACS omega · 2022Article
- Iron Supplementation at the Crossroads of Nutrition and Gut Microbiota: The State of the Art.Nutrients · 2022Review
- Therapeutic approaches to colorectal cancerFrontiers in microbiology · 2022Review
- Deciphering the involvement of iron targets in colorectal cancer: a network biology approach.American journal of translational research · 2022Article
- Pharmacological Mechanism of Pingxiao Formula against Colorectal Cancer.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Differences in the On- and Off-Tumor Microbiota between Right- and Left-Sided Colorectal Cancer.Microorganisms · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perturbations of the colonic microbiota can contribute to the initiation and progression of colorectal cancer, leading to an increase in pathogenic bacteria at the expense of protective bacteria. This can contribute to disease through increasing carcinogenic metabolite/toxin production, inducing inflammation, and activating oncogenic signaling. To limit disease progression, external factors that may influence the colonic microbiota need to be considered in patients with colorectal cancer. One major factor that can influence the colonic microbiota is iron. Iron is an essential micronutrient that is required by both prokaryotes and eukaryotes for cellular function. Most pathogenic bacteria have heightened iron acquisition mechanisms and therefore tend to outcompete protective bacteria for free iron. Colorectal cancer patients often present with anemia due to iron deficiency, and thus they require iron therapy. Depending upon the route of administration, iron therapy has the potential to contribute to a procarciongenic microbiota. Orally administered iron is the common treatment for anemia in these patients but can lead to an increased gut iron concentration. This suggests the need to reassess the route of iron therapy in these patients. Currently, this has only been assessed in murine studies, with human trials being necessary to unravel the potential microbial outcomes of iron therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.