Evidence map›Paper›PMID 32825201›Full record

ArticleJournal of clinical medicine2020

Evaluation of Myocardial Gene Expression Profiling for Superior Diagnosis of Idiopathic Giant-Cell Myocarditis and Clinical Feasibility in a Large Cohort of Patients with Acute Cardiac Decompensation.

Felicitas Escher, Heiko Pietsch, Ganna Aleshcheva, Philip Wenzel, Friedrich Fruhwald, Christian Stumpf, Dirk Westermann, Johann Bauersachs, Frank Enseleit, Frank Ruschitzka and 18 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 19 institutions in 3 countries.

Felicitas EscherInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Heiko PietschInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Ganna AleshchevaInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Philip WenzelUniversity Medical Center Mainz, Department of Cardiology and Center for Thrombosis and Haemostasis, 55131 Mainz, Germany.
Friedrich FruhwaldDepartment of Internal Medicine, Division of Cardiology, Medical University Graz, 8036 Graz, Austria.
Christian StumpfDepartment of Cardiology, Klinikum Bayreuth GmbH, Medical Clinic II, 95445 Bayreuth, Germany.
Dirk WestermannUniversity Heart Center Hamburg, Department of Internal Medicine and Interventional Cardiology, 20251 Hamburg, Germany.
Johann BauersachsDepartment of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Frank EnseleitDepartment of Cardiology, University Hospital Zurich, 8091 Zurich, Switzerland.
Frank RuschitzkaDepartment of Cardiology, University Hospital Zurich, 8091 Zurich, Switzerland.
Herbert NägeleDepartment for Cardiac Insufficiency and Device Therapy, Albertinen-Hospital, 22457 Hamburg, Germany.
Karl-Ludwig LaugwitzDepartment of Cardiology, Klinikum rechts der Isar, 81675 Munich, Germany.
Hendrik HaakeDepartment of Cardiology, Electrophysiology and Intensive Care Medicine, Kliniken Maria Hilf GmbH, 41063 Monchengladbach, Germany.
Norbert FreyDepartment of Internal Medicine III-Cardiology, Angiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Johannes BrachmannDepartment of Internal Medicine, Division of Cardiology, Clinical Center Coburg, 96450 Coburg, Germany.
Kurt Huber3rd Medical Department with Cardiology, Wilhelminenhospital Vienna, 1160 Vienna, Austria.
Rüdiger Christian Braun-DullaeusDepartment of Cardiology und Angiology, University Magdeburg, 39106 Magdeburg, Germany.
Martin W BergmannCardiologicum Hamburg Wandsbek, 22041 Hamburg, Germany.
Jörg StrotmannDepartment of Cardiology, Städtisches Krankenhaus Kiel GmbH, 24116 Kiel, Germany.
Gerian GrönefeldDepartment of Cardiology, Asklepios Klinik Barmbek, 22307 Hamburg, Germany.
Jürgen Krülls-MünchDepartment of Cardiology and Angiology, Carl-Thiem-Klinikum Cottbus gGmbH, 03048 Cottbus, Germany.
Ralf WestenfeldDivision of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine University, 40225 Düsseldorf, Germany.
Carsten SkurkGerman Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.
Ulf LandmesserGerman Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.
Burkert PieskeDepartment of Cardiology, Charité-University Medicine Berlin, Campus Virchow-Klinikum, 13353 Berlin, Germany.
Ulrich M GrossInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Lars MorawietzInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Heinz-Peter SchultheissInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
German Centre for Cardiovascular Research · DECS Diagnostics · DEUniversity Hospital of Zurich · CHAlbertinen Diakoniewerk · DEAsklepios Klinik Barmbek · DEBayreuth Medical Center · DECarl-Thiem-Klinikum Cottbus · DEHeinrich Heine University Düsseldorf · DEJohannes Gutenberg University Mainz · DEKliniken Maria Hilf · DEKlinikum Coburg · DEMedical University of Graz · ATMedizinische Hochschule Hannover · DESchmerzklinik Kiel · DETUM Klinikum · DEUniversität Hamburg · DEUniversity Hospital Magdeburg · DEUniversity Hospital Schleswig-Holstein · DEWilhelminen Hospital · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe diagnostic approach to idiopathic giant-cell myocarditis (IGCM) is based on identifying various patterns of inflammatory cell infiltration and multinucleated giant cells (GCs) in histologic sections taken from endomyocardial biopsies (EMBs). The sampling error for detecting focally located GCs by histopathology is high, however. The aim of this study was to demonstrate the feasibility of gene profiling as a new diagnostic method in clinical practice, namely in a large cohort of patients suffering from acute cardiac decompensation.

Indexed as

endomyocardial biopsygene-expression profilingidiopathic giant-cell myocarditis

Identifiers

PMID32825201
PMCPMC7563288
OpenAlexW3076688321

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.