Evidence map›Paper›PMID 32825113›Full record

ReviewJournal of functional biomaterials2020

Biodegradable Polymeric Micro/Nano-Structures with Intrinsic Antifouling/Antimicrobial Properties: Relevance in Damaged Skin and Other Biomedical Applications.

Mario Milazzo, Giuseppe Gallone, Elena Marcello, Maria Donatella Mariniello, Luca Bruschini, Ipsita Roy, Serena Danti

Open access · goldAbstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Polymer-Based Nanosystems-A Versatile Delivery Approach.Materials (Basel, Switzerland) · 2021
    Review
  7. Article
  8. Antimicrobial Polymer-Based Assemblies: A Review.International journal of molecular sciences · 2021
    Review
  9. Review
  10. Article
  11. Bio-Based Electrospun Fibers for Wound Healing.Journal of functional biomaterials · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Mario MilazzoDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.ORCID 0000-0001-8429-5544
Giuseppe GalloneDepartment of Civil and Industrial Engineering, University of Pisa, 56126 Pisa, Italy.
Elena MarcelloSchool of Life Sciences, University of Westminster, London W1W 6UW, UK.
Maria Donatella MarinielloDoctoral School in Clinical and Translational Sciences, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, via Savi 10, 56126 Pisa, Italy.
Luca BruschiniDepartment of Surgical, Medical, Molecular Pathology and Emergency Medicine, University of Pisa, via Savi 10, 56126 Pisa, Italy.ORCID 0000-0002-6900-1306
Ipsita RoyDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S1 3JD, UK.
Serena DantiDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.ORCID 0000-0002-8155-8537
University of Pisa · ITMassachusetts Institute of Technology · USUniversity of Sheffield · GBUniversity of Westminster · GB

Funding

Bio-Based Industries Joint Undertaking under the European Union Horizon 2020 research program (BBI-H2020) 745839H2020 Marie Skłodowska-Curie Actions 643050H2020 Marie Skłodowska-Curie Actions 794614
6 · The paper itself

Abstract

Bacterial colonization of implanted biomedical devices is the main cause of healthcare-associated infections, estimated to be 8.8 million per year in Europe. Many infections originate from damaged skin, which lets microorganisms exploit injuries and surgical accesses as passageways to reach the implant site and inner organs. Therefore, an effective treatment of skin damage is highly desirable for the success of many biomaterial-related surgical procedures. Due to gained resistance to antibiotics, new antibacterial treatments are becoming vital to control nosocomial infections arising as surgical and post-surgical complications. Surface coatings can avoid biofouling and bacterial colonization thanks to biomaterial inherent properties (e.g., super hydrophobicity), specifically without using drugs, which may cause bacterial resistance. The focus of this review is to highlight the emerging role of degradable polymeric micro- and nano-structures that show intrinsic antifouling and antimicrobial properties, with a special outlook towards biomedical applications dealing with skin and skin damage. The intrinsic properties owned by the biomaterials encompass three main categories: (1) physical-mechanical, (2) chemical, and (3) electrostatic. Clinical relevance in ear prostheses and breast implants is reported. Collecting and discussing the updated outcomes in this field would help the development of better performing biomaterial-based antimicrobial strategies, which are useful to prevent infections.

Indexed as

antifoulingantimicrobialantiviralbiomedical devicebreast implantchronic woundear prosthesiselectrospinningskin

Identifiers

PMID32825113
PMCPMC7563177
OpenAlexW3054366298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.