Evidence map›Paper›PMID 32825101›Full record

ArticleBrain sciences2020

A Translational Study on Acute Traumatic Brain Injury: High Incidence of Epileptiform Activity on Human and Rat Electrocorticograms and Histological Correlates in Rats.

Ilia G Komoltsev, Mikhail V Sinkin, Aleksandra A Volkova, Elizaveta A Smirnova, Margarita R Novikova, Olga O Kordonskaya, Alexander E Talypov, Alla B Guekht, Vladimir V Krylov, Natalia V Gulyaeva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ilia G KomoltsevLaboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerov Str., 117485 Moscow, Russia.
Mikhail V SinkinSklifosovsky Research Institute of Emergency Care, 3 Bolshaya Sucharevskaya Square, 129010 Moscow, Russia.ORCID 0000-0001-5026-0060
Aleksandra A VolkovaLaboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerov Str., 117485 Moscow, Russia.
Elizaveta A SmirnovaLaboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerov Str., 117485 Moscow, Russia.
Margarita R NovikovaLaboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerov Str., 117485 Moscow, Russia.
Olga O KordonskayaSklifosovsky Research Institute of Emergency Care, 3 Bolshaya Sucharevskaya Square, 129010 Moscow, Russia.
Alexander E TalypovSklifosovsky Research Institute of Emergency Care, 3 Bolshaya Sucharevskaya Square, 129010 Moscow, Russia.
Alla B GuekhtResearch and Clinical Center for Neuropsychiatry of Moscow Healthcare Department, 43 Donskaya Str., 115419 Moscow, Russia.
Vladimir V KrylovSklifosovsky Research Institute of Emergency Care, 3 Bolshaya Sucharevskaya Square, 129010 Moscow, Russia.ORCID 0000-0001-7206-8926
Natalia V GulyaevaLaboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerov Str., 117485 Moscow, Russia.ORCID 0000-0002-5380-7954
Institute of Higher Nervous Activity and Neurophysiology · RUMoscow Research and Clinical Center for Neuropsychiatry · RUMoscow State University of Medicine and Dentistry · RUResearch Institute of Emergency Care · RU

Funding

Russian Foundation for Basic Research 18-29-02035Russian Foundation for Basic Research 19-015-00258
6 · The paper itself

Abstract

backgroundIn humans, early pathological activity on invasive electrocorticograms (ECoGs) and its putative association with pathomorphology in the early period of traumatic brain injury (TBI) remains obscure.

methodsWe assessed pathological activity on scalp electroencephalograms (EEGs) and ECoGs in patients with acute TBI, early electrophysiological changes after lateral fluid percussion brain injury (FPI), and electrophysiological correlates of hippocampal damage (microgliosis and neuronal loss), a week after TBI in rats.

resultsEpileptiform activity on ECoGs was evident in 86% of patients during the acute period of TBI, ECoGs being more sensitive to epileptiform and periodic discharges. A "brush-like" ECoG pattern superimposed over rhythmic delta activity and periodic discharge was described for the first time in acute TBI. In rats, FPI increased high-amplitude spike incidence in the neocortex and, most expressed, in the ipsilateral hippocampus, induced hippocampal microgliosis and neuronal loss, ipsilateral dentate gyrus being most vulnerable, a week after TBI. Epileptiform spike incidence correlated with microglial cell density and neuronal loss in the ipsilateral hippocampus.

conclusionEpileptiform activity is frequent in the acute period of TBI period and is associated with distant hippocampal damage on a microscopic level. This damage is probably involved in late consequences of TBI. The FPI model is suitable for exploring pathogenetic mechanisms of post-traumatic disorders.

Indexed as

electrocorticogramsepileptiform dischargeshippocampuslocal field potentialsmicroglianeocortexneurodegenerationpost-traumatic epilepsytraumatic brain injury

Identifiers

PMID32825101
PMCPMC7565553
OpenAlexW3057025464

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.