ArticleAntibiotics (Basel, Switzerland)2020
Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series.
Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Healing the Sole: Combining Natural Plant Extracts and Conventional Drugs in Wound Delivery Systems for Diabetic Foot Ulcer Treatment.International journal of molecular sciences · 2026Review
- Real-World Experience in the Treatment of Biofilm-Associated Wounds Using Medical-Grade Honey: A Retrospective Case Series.Antibiotics (Basel, Switzerland) · 2026Article
- Testing Sonication and Different Transport Media to Enhance Microbial Detection in Hard-to-Heal Venous Leg Ulcers.International wound journal · 2025Observational
- Article
- Exploring the antibacterial and anti-biofilm activity of two Iranian medical-grade kinds of honey on multidrug-resistant Pseudomonas aeruginosa.BMC complementary medicine and therapies · 2025Article
- Treating Infected Non-Healing Venous Leg Ulcers with Medical-Grade Honey: A Prospective Case Series.Antibiotics (Basel, Switzerland) · 2024Article
- Reactive Oxygen Species (ROS)-Mediated Antibacterial Oxidative Therapies: Available Methods to Generate ROS and a Novel Option Proposal.International journal of molecular sciences · 2024Review
- Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis.Antibiotics (Basel, Switzerland) · 2024Review
- Manuka honey as a non-antibiotic alternative againstFrontiers in cellular and infection microbiology · 2024Review
- Evaluation of the Effectiveness of Medical-Grade Honey and Hypericum Perforatum Ointment on Second-Intention Healing of Full-Thickness Skin Wounds in Cats.Animals : an open access journal from MDPI · 2023Article
- The impact of wound pH on the antibacterial properties of Medical Grade Honey when applied to bacterial isolates present in common foot and ankle wounds. An in vitro study.Journal of foot and ankle research · 2023Article
- Incidence of Bacteriobilia and the Correlation with Antibioticoprophylaxis in Low-Risk Patients Submitted to Elective Videolaparoscopic Cholecystectomy: A Randomized Clinical Trial.Antibiotics (Basel, Switzerland) · 2023Article
- The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study.Antibiotics (Basel, Switzerland) · 2023Article
- Use of Medical-Grade Honey to Treat Clinically Infected Heel Pressure Ulcers in High-Risk Patients: A Prospective Case Series.Antibiotics (Basel, Switzerland) · 2023Article
- Medical-Grade Honey Enhances the Healing of Caesarean Section Wounds and Is Similarly Effective to Antibiotics Combined with Povidone-Iodine in the Prevention of Infections-A Prospective Cohort Study.Antibiotics (Basel, Switzerland) · 2023Article
- Therapeutic Potential of Honey and Propolis on Ocular Disease.Pharmaceuticals (Basel, Switzerland) · 2022Review
- L-Mesitran Foam: Evaluation of a New Wound Care Product.Case reports in dermatological medicine · 2022Article
- Medical-Grade Honey Outperforms Conventional Treatments for Healing Cold Sores-A Clinical Study.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Medical grade honey: Hope for wounded white rhinos.Veterinary and animal science · 2021Article
- Treating (Recurrent) Vulvovaginal Candidiasis with Medical-Grade Honey-Concepts and Practical Considerations.Journal of fungi (Basel, Switzerland) · 2021Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic ulcers are at risk of becoming chronic and infected, as diabetics have hampered vascular structures, limiting oxygen and nutrient supply. These wounds can lead to pain, malodor, functional problems, and amputation. The current rise in antibiotic resistance demands for complementary therapies. Medical-grade honey (MGH) forms an attractive option because of its antimicrobial and pro-healing properties. We aim to show the beneficial effects of MGH in infected diabetic ulcers. We present six patients with infected diabetic ulcers, of which some were at risk of (further) amputation. Previous treatments with antibiotics, silver and alginate dressings, surgical closure, and maggot therapy were ineffective; therefore, the treatment was switched to the application of MGH. MGH therapy typically reduced the malodor in a couple of days and controlled infection within 2-3 weeks. MGH also enhanced wound healing by promoting granulation tissue formation, angiogenesis, and re-epithelialization, by decreasing inflammatory and oxidative stress and providing nutrients. Together, wound healing was enhanced, and the patient's quality of life improved. MGH is safe and cost-effective for treating complicated diabetic wounds with (antibiotic-resistant) infections and at risk of amputation. MGH forms a promising alternative or complementary therapy to replace antibiotics for treating locally infected wounds.
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