ReviewAnimals : an open access journal from MDPI2020
Optimal Methods of Documenting Analgesic Efficacy in Neonatal Piglets Undergoing Castration.
Review in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Efficacy of intranasal non-steroidal anti-inflammatory drugs on pain responses in castrated and tail-docked piglets.Porcine health management · 2026Article
- Two restraining devices in connection to surgical castration with or without local anesthesia: effects on piglet stress.Porcine health management · 2025Article
- Behavior of Piglets in an Observation Arena before and after Surgical Castration with Local Anesthesia.Animals : an open access journal from MDPI · 2023Article
- An investigation of the use of ethyl chloride and meloxicam to decrease the pain associated with a single or double incision method of castration in piglets.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Efficacy of inguinal buffered lidocaine and intranasal flunixin meglumine on mitigating physiological and behavioral responses to pain in castrated piglets.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Validation of the Unesp-Botucatu pig composite acute pain scale (UPAPS) in piglets undergoing castration.PloS one · 2023Article
- Comparative Study of Pain-Related Responses of Male Piglets up to Seven Days of Age to the Application of Different Local Anaesthetics and Subsequent Castration.Animals : an open access journal from MDPI · 2022Article
- Role of Topical Anaesthesia in Pain Management of Farm Animals, a Changing Paradigm.Animals : an open access journal from MDPI · 2022Review
- Piglets' acute responses to local anesthetic injection and surgical castration: Effects of the injection method and interval between injection and castration.Frontiers in veterinary science · 2022Article
- Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals.Frontiers in neuroscience · 2022Review
- Efficacy of Intra-Operative Topical Wound Anaesthesia to Mitigate Piglet Castration Pain-A Large, Multi-Centred Field Trial.Animals : an open access journal from MDPI · 2021Article
- Refinements to Animal Models for Biomedical Research.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets. This poses challenges for investigators to optimize trial design and to meet ethical obligations to minimize the number of animals needed. Pain in neonatal piglets may be subtle, transient, and/or variably expressed and, in the absence of validated methods, investigators must rely on using a range of biochemical, physiological and behavioural variables, many of which appear to have very low (or unknown) sensitivity or specificity for documenting pain, or pain-relieving effects. A previous systematic review of this subject was hampered by the high degree of variability in the literature base both in terms of methods used to assess pain and pain mitigation, as well as in outcomes reported. In this setting we provide a narrative review to assist in determining the optimal methods currently available to detect piglet pain during castration and methods to mitigate castration-induced pain. In overview, the optimal outcome variables identified are nociceptive motor and vocal response scores during castration and quantitative sensory-threshold response testing and pain-associated behaviour scores following castration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.