Evidence map›Paper›PMID 32824935›Full record

ArticleAnimals : an open access journal from MDPI2020

Development and Evaluation of a Disease Large Animal Model for Preclinical Assessment of Renal Denervation Therapies.

Armando Pérez de Prado, Claudia Pérez-Martínez, Marta Regueiro-Purriños, Carlos Cuellas-Ramón, María López-Benito, José Manuel Gonzalo-Orden, Rodrigo Estévez-Loureiro, Ana Isabel Cortina-Rivero, David Viñuela-Baragaño, José R Altonaga and 2 more

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Armando Pérez de PradoFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.ORCID 0000-0003-3283-0597
Claudia Pérez-MartínezFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.ORCID 0000-0001-8060-6368
Marta Regueiro-PurriñosFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.
Carlos Cuellas-RamónFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.
María López-BenitoFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.
José Manuel Gonzalo-OrdenFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.
Rodrigo Estévez-LoureiroFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.ORCID 0000-0001-5841-5514
Ana Isabel Cortina-RiveroFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.
David Viñuela-BaragañoFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.
José R AltonagaFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.
Armando TellezAlizée Pathology LLC., Thurmont, MD 21788, USA.ORCID 0000-0002-5485-7507
Felipe Fernández-VázquezFundación Investigación Sanitaria de León, Hospital Universitario de León-Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.ORCID 0000-0001-7187-1290
Hospital de León · ESTecnológico de Monterrey · MX

Funding

Junta de Castilla y León GRS 1001/A/2014
6 · The paper itself

Abstract

New-generation catheters-based renal denervation (RDN) is under investigation for the treatment of uncontrolled hypertension (HTN). We assessed the feasibility of a large animal model of HTN to accommodate the human RDN devices. Ten minipigs were instrumented to measure blood pressure (BP) in an awake-state. HTN was induced with subcutaneous 11-deoxycorticosterone (DOCA, 100 mg/kg) implants. Five months after, the surviving animals underwent RDN with the Symplicity

Indexed as

DOCAhistologyhypertensionimmunohistochemistryradiofrequencyrenal denervationswine

Identifiers

PMID32824935
PMCPMC7552649
OpenAlexW3066645181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.