Evidence map›Paper›PMID 32824931›Full record

ReviewMedicina (Kaunas, Lithuania)2020

An Update on Venous Thromboembolism Rates and Prophylaxis in Hip and Knee Arthroplasty in 2020.

Daniel C Santana, Ahmed K Emara, Melissa N Orr, Alison K Klika, Carlos A Higuera, Viktor E Krebs, Robert M Molloy, Nicolas S Piuzzi

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05312060 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Pneumatic Compression Versus Anti-thromboembolic Exercises: Effects on Edema of the Lower Limbs and the Outcomes of Patients Undergoing Total Hip Arthroplasty: Randomized Controlled Clinical Trial

TypeinterventionalSponsorLuca MarinRan2022 to 2022Enrolled48ConditionsEdema LegArmsPC Pneumatic compression, AE Antithromboembolic exercises
NCT06795698 phase2completednot on this map

The Effect of Prophylactic Anticoagulation on Major Bleeding Events in Hospitalized Chronic Kidney Disease and Lower Limb Fracture Patients. a Phase 2, Randomized, Doble Blind, Control Trial

TypeinterventionalSponsorHospital Civil de GuadalajaraRan2019 to 2024Enrolled61ConditionsFractures, Bone, CKD Stage 4, CKD Stage 3, CKD Stage 5ArmsEnoxaparin
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
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  3. Effectiveness and Safety of Aspirin Versus Other Antithrombotics for VTE After Total Hip and Knee Arthroplasty in Real-World Setting.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniel C SantanaDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0003-4697-1665
Ahmed K EmaraDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
Melissa N OrrDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
Alison K KlikaDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
Carlos A HigueraDepartment of Orthopaedic Surgery, Cleveland Clinic Florida, Weston, FL 33331, USA.
Viktor E KrebsDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
Robert M MolloyDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
Nicolas S PiuzziDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
Cleveland Clinic · USCleveland Clinic Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients undergoing total hip and knee arthroplasty are at high risk for venous thromboembolism (VTE) with an incidence of approximately 0.6-1.5%. Given the high volume of these operations, with approximately one million performed annually in the U.S., the rate of VTE represents a large absolute number of patients. The rate of VTE after total hip arthroplasty has been stable over the past decade, although there has been a slight reduction in the rate of deep venous thrombosis (DVT), but not pulmonary embolism (PE), after total knee arthroplasty. Over this time, there has been significant research into the optimal choice of pharmacologic VTE prophylaxis for individual patients, with the objective to reduce the rate of VTE while minimizing adverse side effects such as bleeding. Recently, aspirin has emerged as a promising prophylactic agent for patients undergoing arthroplasty due to its similar efficacy and good safety profile compared to other pharmacologic agents. However, there is no evidence to date that clearly demonstrates the superiority of any given prophylactic agent. Therefore, this review discusses (1) the current prevalence and trends in VTE after total hip and knee arthroplasty and (2) provides an update on pharmacologic VTE prophylaxis in regard to aspirin usage.

Indexed as

Arthroplasty, Replacement, HipArthroplasty, Replacement, KneeAspirinFibrinolytic AgentsHemorrhageHumansIncidencePostoperative ComplicationsPrevalencePulmonary EmbolismReoperationVenous ThromboembolismAspirinFibrinolytic AgentsarthroplastyDVTjoint replacementpulmonary embolismsurgical complicationsvenous thromboembolism

Identifiers

PMID32824931
PMCPMC7558636
OpenAlexW3072813939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.