Evidence map›Paper›PMID 32824862›Full record

ArticleInternational journal of molecular sciences2020

PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation.

Hung-Che Chien, Paul L Greenhaff, Dumitru Constantin-Teodosiu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Hung-Che ChienSchool of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.ORCID 0000-0002-2500-0299
Paul L GreenhaffSchool of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.
Dumitru Constantin-TeodosiuSchool of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.
University of Nottingham · GB

Funding

Arthritis Research UK 19891Medical Research Council MR/K00414X/1Medical Research Council grant number MR/K00414X/1National Defense Medical Centre, Taipei 11490, Taiwan xxxxx
6 · The paper itself

Abstract

The mechanisms behind the reduction in muscle pyruvate dehydrogenase complex (PDC)-controlled carbohydrate (CHO) oxidation during chronic high-fat dietary intake are poorly understood, as is the basis of CHO oxidation restoration during muscle contraction. C2C12 myotubes were treated with (300 μM) palmitate or without (control) for 16 h in the presence and absence of electrical pulse stimulation (EPS, 11.5 V, 1 Hz, 2 ms). Compared to control, palmitate reduced cell glucose uptake (

Indexed as

Muscle ContractionAcetylcarnitineAction PotentialsAdenosine TriphosphateAnimalsCell LineForkhead Box Protein O1GlucoseMiceMitochondria, MuscleMuscle Fibers, SkeletalPalmitatesPPAR deltaPyruvate Dehydrogenase Acetyl-Transferring KinaseAcetylcarnitineAdenosine TriphosphateForkhead Box Protein O1Foxo1 protein, mouseGlucosePalmitatesPdk4 protein, mousePPAR deltaPyruvate Dehydrogenase Acetyl-Transferring Kinasecontractionfree fatty acidsinsulin resistancemuscle cell

Identifiers

PMID32824862
PMCPMC7460628
OpenAlexW3073584816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.