Evidence map›Paper›PMID 32824826›Full record

ArticleInternational journal of environmental research and public health2020

Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020.

Giuseppina Campisi, Rodolfo Mauceri, Francesco Bertoldo, Giordana Bettini, Matteo Biasotto, Giuseppe Colella, Ugo Consolo, Olga Di Fede, Gianfranco Favia, Vittorio Fusco and 14 more

Registry-linked trialOpen access · goldAbstract readConference ProceedingsConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06072404 (Comparative Analysis of Different Protocols for Dental Exactions in Patients at Risk of MRONJ), which is not on this map. Cited by 92 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 3 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06072404 phase1 / phase2completednot on this map

Comparative Analysis of Different Protocols for Dental Exactions in Patients at Risk of MRONJ: Case-control Study

TypeinterventionalSponsorUniversity of PalermoRan2018 to 2020Enrolled117ConditionsMEDICATION RELATED OSTEONECROSIS OF THE JAWArmsOxigenOzone_Insufflation
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 178 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. A qualitative analysis of dental challenges for oncology patients receiving bone-modifying agents.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  7. Article
  8. Management of MRONJ: comparison between SIPMO-SICMF and AAOMS consensus statements and clinical-economic implications for the national health system.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Antimicrobial Stewardship in oral and maxillofacial surgery: melting the iceberg.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 15 institutions in 1 country.

Giuseppina CampisiDepartment of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-9443-0495
Rodolfo MauceriDepartment of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-4008-6502
Francesco BertoldoIAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy.ORCID 0000-0002-5175-7340
Giordana BettiniIAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy.ORCID 0000-0002-4314-3277
Matteo BiasottoDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy.
Giuseppe ColellaDepartment of Medical, Surgical and Dental Speciality, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Ugo ConsoloDepartment of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0001-5557-3285
Olga Di FedeDepartment of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-5562-7420
Gianfranco FaviaDepartment of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.
Vittorio FuscoIAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy.
Mario GabrieleDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy.
Antonio Lo CastoDepartment of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy.
Lorenzo Lo MuzioDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy.ORCID 0000-0003-4633-4893
Antonia MarcianòDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.
Marco MascittiDepartment of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy.ORCID 0000-0002-7304-3752
Marco MeletiDepartment of Medicine and Surgery, University of Parma, 43125 Parma, Italy.
Michele D MignognaDepartment of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Napoli, Italy.
Giacomo OteriDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.ORCID 0000-0002-0941-1645
Vera PanzarellaDepartment of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-6339-6020
Umberto RomeoDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Roma, Italy.ORCID 0000-0003-2439-2187
Andrea SantarelliDepartment of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy.ORCID 0000-0003-4218-3354
Paolo VescoviIAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy.
Claudio MarchettiIAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy.ORCID 0000-0002-4178-4257
Alberto BedogniIAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy.ORCID 0000-0003-4742-4508
University of Palermo · ITUniversity of Messina · ITMarche Polytechnic University · ITUniversity of Padua · ITUniversity of Parma · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITSapienza University of Rome · ITUniversity of Bari Aldo Moro · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Foggia · ITUniversity of Modena and Reggio Emilia · ITUniversity of Naples Federico II · ITUniversity of Pisa · ITUniversity of Trieste · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference-held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)-after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SICMF and SIPMO), written on the inputs of the experts of the Italian Allied Committee on ONJ (IAC-ONJ). The conference focused on the topic of MRONJ, and in particular on the common practices at risk of inappropriateness in MRONJ diagnosis and therapy, as well as on MRONJ prevention and the dental management of patients at risk of MRONJ. It is a matter of cancer and osteometabolic patients that are at risk since being exposed to several drugs with antiresorptive (i.e., bisphosphonates and denosumab) or, more recently, antiangiogenic activities. At the same time, the Conference traced for dentists and oral surgeons some easy applicable indications and procedures to reduce MRONJ onset risk and to diagnose it early. Continuous updating on these issues, so important for the patient community, is recommended.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsDiphosphonatesHumansItalyQuality of LifeBone Density Conservation AgentsDiphosphonatesantiangiogenic agentsantiresorptive drugsbisphosphonatescancerdenosumabdentistryMRONJoral surgeryosteoporosisprevention models

Identifiers

PMID32824826
PMCPMC7460511
OpenAlexW3074604292

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Registered trials

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