Trial reportInternational journal of environmental research and public health2020
High-Flow Oxygen through Nasal Cannula vs. Non-Invasive Ventilation in Hypercapnic Respiratory Failure: A Randomized Clinical Trial.
Trial report in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 9 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- High-Flow Nasal Cannula in Hypercapnic Respiratory Failure: An Updated Systematic Review and Meta-Analysis.The clinical respiratory journal · 2026Pooled it
- High-Flow Nasal Cannula Versus Noninvasive Ventilation in the Treatment of Hypercapnic Respiratory Failure: Meta-Analysis of Randomized Controlled Trials.Journal of evidence-based medicine · 2026Pooled it
- Comparison of clinical outcomes between high-flow nasal cannula and non-invasive ventilation in acute exacerbation of COPD: a meta-analysis of randomized controlled trials.BMC pulmonary medicine · 2025Pooled it
- High flow nasal cannula versus noninvasive ventilation in the treatment of acute hypercapnic respiratory failure: A systematic review and meta-analysis.The clinical respiratory journal · 2023Pooled it
- High-Flow Nasal Oxygen versus Noninvasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients: A Meta-Analysis of Randomized Controlled Trials.Canadian respiratory journal · 2023Pooled it
- Comparison of High Flow Nasal Therapy with Non-Invasive Ventilation and Conventional Oxygen Therapy for Acute Hypercapnic Respiratory Failure: A Meta-Analysis of Randomized Controlled Trials.International journal of chronic obstructive pulmonary disease · 2023Pooled it
- High-flow nasal cannula versus non-invasive ventilation for acute hypercapnic respiratory failure in adults: a systematic review and meta-analysis of randomized trials.Critical care (London, England) · 2022Pooled it
- High flow nasal oxygen for acute type two respiratory failure: a systematic review.F1000Research · 2021Pooled it
- High-Flow Nasal Cannula in Hypercapnic Respiratory Failure: A Systematic Review and Meta-Analysis.Canadian respiratory journal · 2020Pooled it
- High flow nasal cannula oxygen therapy versus non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: a randomized controlled non-inferiority trial.Critical care (London, England) · 2024Trial
- Management of hypercapnic acute respiratory failure with high-flow nasal cannula therapy: A narrative review.Annals of intensive care · 2026Review
- My approach to respiratory sepsis: pulmonary.Breathe (Sheffield, England) · 2026Review
- High-Flow Nasal Oxygen in Patients with Acute Hypercapnic Respiratory Failure: A Narrative Review of the Physiological Rationale and Clinical Evidence.Journal of clinical medicine · 2024Review
- Review
- Acute dyspnea in the emergency department: a clinical review.Internal and emergency medicine · 2023Review
- High-Flow Nasal Cannula versus Noninvasive Ventilation in AECOPD Patients with Respiratory Acidosis: A Retrospective Propensity Score-Matched Study.Canadian respiratory journal · 2023Article
- Effects of high-flow nasal cannula in patients with mild to moderate hypercapnia: a prospective observational study.Acute and critical care · 2021Article
- Effectiveness and Harms of High-Flow Nasal Oxygen for Acute Respiratory Failure: An Evidence Report for a Clinical Guideline From the American College of Physicians.Annals of internal medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-flow oxygen through nasal cannula (HFNC) provides adequate oxygenation and can be an alternative to noninvasive ventilation (NIV) for patients with hypoxemic respiratory failure. The aim of the present study was to assess the efficacy of HFNC versus NIV in hypercapnic respiratory failure. Patients (n = 40) who were admitted to the Emergency Department of Alexandra Hospital due to hypercapnic respiratory failure (PaCO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.