Evidence map›Paper›PMID 32824681›Full record

ArticleInternational journal of molecular sciences2020

The Role of Atypical Cannabinoid Ligands O-1602 and O-1918 on Skeletal Muscle Homeostasis with a Focus on Obesity.

Anna C Simcocks, Lannie O'Keefe, Kayte A Jenkin, Lauren M Cornall, Esther Grinfeld, Michael L Mathai, Deanne H Hryciw, Andrew J McAinch

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Treatment of Diet-Induced Obese Rats with CBInternational journal of molecular sciences · 2023
    Article
  5. Article
  6. CBInternational journal of molecular sciences · 2022
    Article
  7. GPR18-Mediated Relaxation of Human Isolated Pulmonary Arteries.International journal of molecular sciences · 2022
    Article
  8. The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Anna C SimcocksInstitute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia.
Lannie O'KeefeInstitute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia.
Kayte A JenkinInstitute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia.
Lauren M CornallInstitute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia.
Esther GrinfeldInstitute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia.
Michael L MathaiInstitute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia.ORCID 0000-0001-8783-2122
Deanne H HryciwInstitute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia.ORCID 0000-0003-1697-8890
Andrew J McAinchInstitute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia.ORCID 0000-0002-8762-4865
Victoria University · AUAustralian Institute for Musculoskeletal Science · AUCamden and Campbelltown Hospitals · AUFlorey Institute of Neuroscience and Mental Health · AUGriffith University · AU

Funding

Allen Foundation Project ID 2011.385
6 · The paper itself

Abstract

O-1602 and O-1918 are atypical cannabinoid ligands for GPR55 and GPR18, which may be novel pharmaceuticals for the treatment of obesity by targeting energy homeostasis regulation in skeletal muscle. This study aimed to determine the effect of O-1602 or O-1918 on markers of oxidative capacity and fatty acid metabolism in the skeletal muscle. Diet-induced obese (DIO) male Sprague Dawley rats were administered a daily intraperitoneal injection of O-1602, O-1918 or vehicle for 6 weeks. C

Indexed as

HomeostasisAdaptor Proteins, Signal TransducingAdultAnimalsAnisolesCannabidiolCell LineCells, CulturedCyclohexanesFatty AcidsFemaleHumansMaleMiceMiddle AgedMuscle, Skeletal1,3-dimethoxy-5-methyl-2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)benzeneAdaptor Proteins, Signal TransducingAnisolesAPPL2 protein, humanCannabidiolCyclohexanesFatty AcidsGPR18 protein, humanNFATC1 protein, humanNFATC Transcription FactorsO-1602 compoundPDK4 protein, humanPPAR gammaPyruvate Dehydrogenase Acetyl-Transferring KinaseReceptors, G-Protein-CoupledAtypical CannabinoidsGPR18O-1602O-1918obesity and skeletal muscle

Identifiers

PMID32824681
PMCPMC7460607
OpenAlexW3065549176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.