Evidence map›Paper›PMID 32824480›Full record

Trial reportNutrients2020

PHAGE-2 Study: Supplemental Bacteriophages Extend

Diana S Grubb, Scott D Wrigley, Kimberley E Freedman, Yuren Wei, Allegra R Vazquez, Roxanne E Trotter, Taylor C Wallace, Sarah A Johnson, Tiffany L Weir

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05750433 (PHAGE 3), which is not on this map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05750433 nacompletednot on this mapstarted 2021, after this paper: background citation

PHAGE 3: Determination of Phage and Probiotic Synergistic Effects on Gastrointestinal Health

TypeinterventionalSponsorColorado State UniversityRan2021 to 2024Enrolled120ConditionsGastrointestinal DysfunctionArmsPreforPro+B. subtilis DE111 probiotics, Placebo, B. subtilis DE111
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. The Potential of Bacteriophage Therapy as an Alternative Treatment Approach for Antibiotic-Resistant Infections.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024
    Pooled it
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  4. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Diana S GrubbIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Scott D WrigleyIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Kimberley E FreedmanIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Yuren WeiIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Allegra R VazquezIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Roxanne E TrotterIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Taylor C WallaceThink Healthy Group, 1301 20th Street, NW, #413, Washington, DC 20036, USA.ORCID 0000-0002-9403-2745
Sarah A JohnsonFunctional Foods & Human Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Tiffany L WeirIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0001-5423-7140
Colorado State University · USGeorge Mason University · US

Funding

Deerland Enzymes 532727
6 · The paper itself

Abstract

Probiotics are increasingly used by consumers and practitioners to reduce gastrointestinal (GI) distress and improve gut function. Here, we sought to determine whether the addition of supplemental bacteriophages (PreforPro) could enhance the effects of a common probiotic,

Indexed as

BacteriophagesBifidobacterium animalisDietary SupplementsHealthy VolunteersAdolescentAdultAgedDouble-Blind MethodFatty Acids, VolatileFemaleGastrointestinal MicrobiomeHumansLactobacillusMaleMiddle AgedProbioticsFatty Acids, VolatileRNA, Ribosomal, 16SbacteriophageBifidobacteriumgut microbiotaintestinal healthmicrobiomeprobiotic

Identifiers

PMID32824480
PMCPMC7468981
OpenAlexW3049284761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.