ReviewInternational journal of molecular sciences2020
Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
182 citing papers in PubMed, 12 syntheses or guidelines pooled it, 308 citations in OpenAlex.
- Residential green spaces and neurodegenerative diseases in middle-aged and older adults: a systematic review and dose-response meta-analysis.Archives of public health = Archives belges de sante publique · 2026Pooled it
- Pooled it
- Exercise prescription to improve executive functioning in children and adolescents with attention deficit hyperactivity disorder: a network meta-analysis.Frontiers in psychiatry · 2026Pooled it
- The effect of physical activity on Parkinson's disease outcomes in patients with bilateral subthalamic nucleus deep brain stimulation: a systematic review.Frontiers in neurology · 2026Pooled it
- Exercise-based interventions for post-stroke depression: an overview of systematic reviews and evidence mapping.Frontiers in neurology · 2026Pooled it
- Cortical Neuroprotective Mechanisms of Exercise Training in Post-Traumatic Brain Injury: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Exploring the impact of exercise-induced BDNF on neuroplasticity in neurodegenerative and neuropsychiatric conditions.Molecular biology reports · 2025Pooled it
- Combinations of physical and cognitive training for subcortical neurodegenerative diseases with physical, cognitive and behavioral symptoms: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Network meta-analysis of the intervention effects of different exercise measures on Sarcopenia in cancer patients.BMC public health · 2024Pooled it
- A network meta-analysis of the effect of physical exercise on core symptoms in patients with autism spectrum disorders.Frontiers in neurology · 2024Pooled it
- The relationship between physical activity and cognitive function in people with epilepsy: A systematic review.Epilepsy & behavior : E&B · 2023Pooled it
- Overview of Meta-Analyses of Five Non-pharmacological Interventions for Alzheimer's Disease.Frontiers in aging neuroscience · 2020Pooled it
- Resistance Training Improves Cognitive Function and Depression Without Changing BDNF Levels in People Living with HIV: a Randomized Controlled Clinical Trial.AIDS and behavior · 2025Trial
- Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson's disease patients.Translational neurodegeneration · 2022Trial
- Biological mechanisms of different exercise modalities in improving sleep disorders: A review.IBRO neuroscience reports · 2026Review
- Article
- Effects of Kalanchoe pinnata, exercise, and stimulation on neuroinflammation, redox homeostasis, and neuropathic pain in a Wistar-rat model.World journal of experimental medicine · 2026Article
- Rehabilitation strategies for atypical parkinsonian syndromes: A scoping review of progressive supranuclear palsy, multiple system atrophy, corticobasal syndrome, and dementia with Lewy bodies.Journal of Parkinson's disease · 2026Review
- Physical Activity and Purkinje Cells: Mechanisms of Cerebellar Plasticity and Neuroprotection.Journal of functional morphology and kinesiology · 2026Review
- Exercise Training Interventions as Therapeutic Approaches in Substance Use Disorder Treatment: A Scoping Review of Direct Clinical Outcomes and Implementation Strategies.Diseases (Basel, Switzerland) · 2026Review
122 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical exercise (PE) improves physical performance, mental status, general health, and well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE is beneficial for people suffering from neuro-degenerative diseases because it improves the production of neurotrophic factors, neurotransmitters, and hormones. PE promotes neuronal survival and neuroplasticity and also optimizes neuroendocrine and physiological responses to psychosocial and physical stress. PE sensitizes the parasympathetic nervous system (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.