ArticleInternational journal of molecular sciences2020
Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A highly sensitive quantitative method of polysialic acid reveals its unique changes in brain aging and neuropsychiatric disorders.Scientific reports · 2025Article
- Development of a permethylation-based detection method for oligo/polysialic acid structures via tandem MALDI-TOF mass spectrometry.BBA advances · 2025Article
- The dynamic brain N-glycome.Glycoconjugate journal · 2022Review
- Comprehensive Analysis of Oligo/Polysialylglycoconjugates in Cancer Cell Lines.International journal of molecular sciences · 2022Article
- Polysialylation in a DISC1 Mutant Mouse.International journal of molecular sciences · 2022Article
- Polysialic Acid in the Immune System.Frontiers in immunology · 2021Review
- Comparative Studies of Polysialic Acids Derived from Five Different Vertebrate Brains.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Polysialic acid (polySia/PSA) is an anionic glycan polymer of sialic acid, and it mostly modifies the neural cell adhesion molecule (NCAM) in mammalian brains. Quality and quantity of the polySia of the polySia-NCAM is spatio-temporally regulated in normal brain development and functions, and their impairments are reported to be related to diseases, such as psychiatric disorders and cancers. Therefore, precise understanding of the state of polySia-NCAM structure would lead to the diagnosis of diseases for which their suitable evaluation methods are necessary. In this study, to develop these evaluation methods, structures of polySia-NCAM from mouse brains at six different developmental stages were analyzed by several conventional and newly developed methods. Integrated results of these experiments clearly demonstrated the existence of different types of polySia-NCAMs in developing brains. In addition, combinational analyses were shown to be useful for precise understanding of the quantity and quality of polySia, which can provide criteria for the diagnosis of diseases.
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