Evidence map›Paper›PMID 32824344›Full record

ArticleAntioxidants (Basel, Switzerland)2020

Iron Overload, Oxidative Stress and Calcium Mishandling in Cardiomyocytes: Role of the Mitochondrial Permeability Transition Pore.

Richard Gordan, Nadezhda Fefelova, Judith K Gwathmey, Lai-Hua Xie

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Research progress of ferroptosis in obesity and its complications.Journal of physiology and biochemistry · 2026
    Review
  5. Chemo-/radiotherapy-induced cardiomyopathy: roles of mitochondria and endoplasmic reticulum.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. The role of mitochondria in iron overload-induced damage.Journal of translational medicine · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Multifaceted role of ferroptosis in cardiovascular disease.Acta biochimica et biophysica Sinica · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Richard GordanDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ 07103, USA.
Nadezhda FefelovaDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ 07103, USA.
Judith K GwathmeyDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ 07103, USA.
Lai-Hua XieDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0000-0003-2600-2269
Rutgers, The State University of New Jersey · US

Funding

Antiarrhythmic Mechanisms in the Hearts of Hibernating MammalsR01HL097979 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI XIE, LAI-HUA · 2010 to 2015
$1.9M
American Heart Association 19TPA34900003NHLBI NIH HHS HL97979; HL133294
6 · The paper itself

Abstract

Iron (Fe) plays an essential role in many physiological processes. Hereditary hemochromatosis or frequent blood transfusions often cause iron overload (IO), which can lead to cardiomyopathy and arrhythmias; however, the underlying mechanism is not well defined. In the present study, we assess the hypothesis that IO promotes arrhythmias via reactive oxygen species (ROS) production, mitochondrial membrane potential (∆

Indexed as

arrhythmiacalcium dynamicsheartiron overloadmitochondriaoxidative stress

Identifiers

PMID32824344
PMCPMC7465659
OpenAlexW3049738088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.