ArticlePathogens (Basel, Switzerland)2020
Comparative Pathology of Domestic Pigs and Wild Boar Infected with the Moderately Virulent African Swine Fever Virus Strain "Estonia 2014".
Article in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 50 citations in OpenAlex.
- Domestication-Driven Expansion and Structural Convergence of the Porcine Antiviral Interferon Repertoire.Biomolecules · 2026Article
- Comparative evaluation of histopathological lesions and viral antigen distribution in domestic pigs and wild boar inoculated intranasally with the highly virulent ASFV genotype II strain "Armenia 2007".Veterinary research · 2026Article
- Infection of the Conceptus With African Swine Fever Virus Following Artificial Insemination in Sows: A Pathological Study.Transboundary and emerging diseases · 2026Article
- How the wild things are: comparative T cell phenotyping and memory T cell identification in wild boar and domestic pigs.Frontiers in immunology · 2026Article
- Dynamics of leukocyte populations, immune-regulatory cytokines, and biochemical parameters in wild boar and domestic pigs experimentally infected with a virulent African swine fever virus genotype II strain.Frontiers in immunology · 2026Article
- Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways.Virulence · 2025Review
- Intranasal inoculation with African swine fever virus genotype II reveals dose-dependent infectivity, pathogenesis and diagnostic challenges in pigs.The veterinary quarterly · 2025Article
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- Viral Distribution of Wild Boar Exposed to Low (Vaccine Candidate) and High Virulence African Swine Fever Virus Isolates: Immunohistochemical Characterization.Transboundary and emerging diseases · 2025Article
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- Complete genome analysis of the African swine fever virus genotypes II and IX responsible for the 2021 and 2023 outbreaks in Rwanda.Frontiers in veterinary science · 2025Article
- Tertiary lymphoid organs in wild boar exposed to a low-virulent isolate of African swine fever virus.The veterinary quarterly · 2024Article
- Review
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- Comparative evaluation of disease dynamics in wild boar and domestic pigs experimentally inoculated intranasally with the European highly virulent African swine fever virus genotype II strain "Armenia 2007".Veterinary research · 2024Article
- Host immune responses against African swine fever virus: Insights and challenges for vaccine development.Open veterinary journal · 2023Review
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- Assessment of African swine fever vaccine candidate ASFV-G-∆MGF in a reversion to virulence study.NPJ vaccines · 2023Article
- Complete genome analysis of African swine fever virus genotypes II, IX and XV from domestic pigs in Tanzania.Scientific reports · 2023Article
- Article
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9 authors at 1 institution in 1 country.
Funding
Abstract
Endemically infected European wild boar are considered a major reservoir of African swine fever virus in Europe. While high lethality was observed in the majority of field cases, strains of moderate virulence occurred in the Baltic States. One of these, "Estonia 2014", led to a higher number of clinically healthy, antibody-positive animals in the hunting bag of North-Eastern Estonia. Experimental characterization showed high virulence in wild boar but moderate virulence in domestic pigs. Putative pathogenic differences between wild boar and domestic pigs are unresolved and comparative pathological studies are limited. We here report on a kinetic experiment in both subspecies. Three animals each were euthanized at 4, 7, and 10 days post infection (dpi). Clinical data confirmed higher virulence in wild boar although macroscopy and viral genome load in blood and tissues were comparable in both subspecies. The percentage of viral antigen positive myeloid cells tested by flow cytometry did not differ significantly in most tissues. Only immunohistochemistry revealed consistently higher viral antigen loads in wild boar tissues in particular 7 dpi, whereas domestic pigs already eliminated the virus. The moderate virulence in domestic pigs could be explained by a more effective viral clearance.
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