Evidence map›Paper›PMID 32824307›Full record

ArticleInternational journal of molecular sciences2020

Association of Electronegative LDL with Macrophage Foam Cell Formation and CD11c Expression in Rheumatoid Arthritis Patients.

Ching-Kun Chang, Po-Ku Chen, Joung-Liang Lan, Shih-Hsin Chang, Tsu-Yi Hsieh, Pei-Jyuan Liao, Chu-Huang Chen, Der-Yuan Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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  11. Research of Pathogenesis and Novel Therapeutics in Arthritis 2.0.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ching-Kun ChangRheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan.
Po-Ku ChenRheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan.
Joung-Liang LanTranslational Medicine Laboratory, China Medical University Hospital, Taichung 404, Taiwan.
Shih-Hsin ChangTranslational Medicine Laboratory, China Medical University Hospital, Taichung 404, Taiwan.
Tsu-Yi HsiehDepartment of Medical Education and Research, Taichung Veterans General Hospital, Taichung 407, Taiwan.
Pei-Jyuan LiaoRheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan.
Chu-Huang ChenVascular and Medicinal Research, Texas Heart Institute, Houston, TX 6770, USA.
Der-Yuan ChenRheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan.
China Medical University · TWChina Medical University Hospital · TWShinshu University · JPTaichung Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L5, the most negatively charged subfraction of low-density lipoprotein (LDL), is implicated in atherogenesis, but the pathogenic association is relatively unexplored in patients with rheumatoid arthritis (RA). We examined the role of L5 LDL in macrophage foam cell formation and the association of L5 with CD11c expression in THP-1 cells and RA patients. Using quantitative real-time PCR, we determined mRNA expression levels of

Indexed as

AgedArthritis, RheumatoidCD11c AntigenFemaleFoam CellsHumansInterleukin-6Interleukin-8Lipoproteins, LDLMaleMiddle AgedTHP-1 CellsTumor Necrosis Factor-alphaCD11c AntigenInterleukin-6Interleukin-8Lipoproteins, LDLTumor Necrosis Factor-alphaatherosclerosisCD11c expressionL5macrophage foam cellrheumatoid arthritis (RA)

Identifiers

PMID32824307
PMCPMC7461586
OpenAlexW3049131828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.