Evidence map›Paper›PMID 32824299›Full record

ArticlePharmaceutics2020

Combination Delivery of Alpha-Tocopheryl Succinate and Curcumin Using a GSH-Sensitive Micelle (PAH-SS-PLGA) to Treat Pancreatic Cancer.

Tilahun Ayane Debele, Hung-Chang Wu, Shang-Rung Wu, Yan-Shen Shan, Wen-Pin Su

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Vitamin E in the management of pancreatic cancer: A scoping review.World journal of gastrointestinal oncology · 2023
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tilahun Ayane DebeleInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, No.138, Sheng Li Road, Tainan 704, Taiwan.
Hung-Chang WuDepartment of Internal Medicine, Chi Mei Medical Center, Tainan 710, Taiwan.
Shang-Rung WuInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Yan-Shen ShanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, No.138, Sheng Li Road, Tainan 704, Taiwan.
Wen-Pin SuInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, No.138, Sheng Li Road, Tainan 704, Taiwan.
National Cheng Kung University · TWNational Cheng Kung University Hospital · TWChi Mei Medical Center · TW

Funding

Chi Mei Medical Center CMNCKU10505Chi Mei Medical Center CMNCKU10609Chi Mei Medical Center CMNCKU10715Ministry of Science and Technology, Taiwan MOST 106-2314-B-006-074-MY3Ministry of Science and Technology, Taiwan MOST 108-2811-B-006-501Ministry of Science and Technology, Taiwan MOST 108-2811-B-006-525Ministry of Science and Technology, Taiwan MOST 109-2314-B-006-078Ministry of Science and Technology, Taiwan MOST 109-2314-B-006-084-MY3National Cheng Kung University HUA 109-3-7-156National Cheng Kung University Hospital NCKUH-10902034
6 · The paper itself

Abstract

Pancreatic cancer is one of the highest causes of mortality throughout the world; thus, it requires an effective treatment strategy. Some chemotherapeutic agents used in the clinics or under clinical trials are hydrophobic and have poor aqueous solubility; consequently, they also have minimal systemic bioavailability. Nanoparticle-based drug delivery tactics have the potential for overcoming these limitations and enhancing their therapeutic efficacy. Herein, a glutathione (GSH)-sensitive micelle (PAH-SS-PLGA) was synthesized for the combined delivery of alpha-tocopheryl succinate (TOS) and curcumin to improve its therapeutic efficacy. The chemical structures of PAH-SS-PLGA were analyzed using Proton Nuclear Magnetic Resonance (

Indexed as

alpha-tocopheryl succinatecurcuminGSH-sensitive micellepoly(allylamine hydrochloride) (PAH)poly(lactic-co-glycolic acid) (PLGA)

Identifiers

PMID32824299
PMCPMC7464675
OpenAlexW3049590433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.