Evidence map›Paper›PMID 32824223›Full record

ArticleNutrients2020

Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models.

Csilla Ari, Cem Murdun, Craig Goldhagen, Andrew P Koutnik, Sahil R Bharwani, David M Diamond, Mark Kindy, Dominic P D'Agostino, Zsolt Kovacs

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  10. Ketogenic diet for mood disorders from animal models to clinical application.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Review
  11. Article
  12. Article
  13. Ketone BodyOxidative medicine and cellular longevity · 2022
    Article
  14. Review
  15. Mitophagy and the Brain.International journal of molecular sciences · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Csilla AriDepartment of Psychology, Behavioral Neuroscience Research Laboratory, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0002-8677-823X
Cem MurdunDepartment of Molecular Pharmacology and Physiology, Laboratory of Metabolic Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0003-2389-8194
Craig GoldhagenDepartment of Molecular Pharmacology and Physiology, Laboratory of Metabolic Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Andrew P KoutnikDepartment of Molecular Pharmacology and Physiology, Laboratory of Metabolic Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Sahil R BharwaniDepartment of Psychology, Behavioral Neuroscience Research Laboratory, University of South Florida, Tampa, FL 33620, USA.
David M DiamondDepartment of Psychology, Behavioral Neuroscience Research Laboratory, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0003-4155-8687
Mark KindyDepartment of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-0144-2172
Dominic P D'AgostinoKetone Technologies, Tampa, FL 33612, USA.ORCID 0000-0001-9652-181X
Zsolt KovacsSavaria Department of Biology, ELTE Eötvös Loránd University, Savaria University Centre, Károlyi Gáspár tér 4., 9700 Szombathely, Hungary.
University of South Florida · USFlorida Institute for Human and Machine Cognition · USEötvös Loránd University · HU

Funding

BLRD Research Career Scientist Award ApplicationIK6BX005239 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI KINDY, MARK S. · 2020 to 2025
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BLRD VA IK6 BX005239National Development Agency of Hungary TIOP-1.3.1.-07/2-2F-2009-2008Office of Naval Research N000141310062OTKA K124558Quest Nutrition 001
6 · The paper itself

Abstract

Nutritional ketosis has been proven effective for neurometabolic conditions and disorders linked to metabolic dysregulation. While inducing nutritional ketosis, ketogenic diet (KD) can improve motor performance in the context of certain disease states, but it is unknown whether exogenous ketone supplements-alternatives to KDs-may have similar effects. Therefore, we investigated the effect of ketone supplements on motor performance, using accelerating rotarod test and on postexercise blood glucose and

Indexed as

Dietary Supplements3-Hydroxybutyric AcidAnimalsBlood GlucoseButylene GlycolsCarbohydrate Metabolism, Inborn ErrorsDiet, KetogenicHumansKetonesKetosisMaleMiceModels, AnimalMonosaccharide Transport ProteinsMotor ActivityRats3-Hydroxybutyric AcidBlood GlucoseButylene GlycolsKetonesMonosaccharide Transport ProteinsTriglyceridesketogenic dietketone esterketone saltMCTrotarodR-βHB

Identifiers

PMID32824223
PMCPMC7468837
OpenAlexW3049488587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.