Evidence map›Paper›PMID 32824094›Full record

ArticleInternational journal of molecular sciences2020

In Silico Structural and Biochemical Functional Analysis of a Novel

Michal Cohen, Emanuele Pignatti, Monica Dines, Adi Mory, Nina Ekhilevitch, Rachel Kolodny, Christa E Flück, Dov Tiosano

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Michal CohenPediatric Endocrinology Unit, Ruth Rappaport Children's Hospital, Rambam Healthcare Campus, Haifa 352540, Israel.
Emanuele PignattiPediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, University Hospital Inselspital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-5372-5692
Monica DinesSagol Department of Neurobiology, University of Haifa, Mount Carmel, Haifa 31905, Israel.
Adi MoryGenetics Institute, Rambam Health Care Campus, Haifa 3525408, Israel.
Nina EkhilevitchGenetics Institute, Rambam Health Care Campus, Haifa 3525408, Israel.ORCID 0000-0001-8996-5586
Rachel KolodnyDepartment of Computer Science, University of Haifa, Mount Carmel, Haifa 3498838, Israel.ORCID 0000-0001-8523-1614
Christa E FlückPediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, University Hospital Inselspital, University of Bern, 3010 Bern, Switzerland.
Dov TiosanoPediatric Endocrinology Unit, Ruth Rappaport Children's Hospital, Rambam Healthcare Campus, Haifa 352540, Israel.
Rambam Health Care Campus · ILTechnion – Israel Institute of Technology · ILUniversity of Bern · CHCarmel (Israel) · ILUniversity of Haifa · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Classical congenital adrenal hyperplasia (CAH) caused by pathogenic variants in the steroid 21-hydroxylase gene (

Indexed as

Computer SimulationChild, PreschoolEvolution, MolecularFemaleHumansInfantInfant, NewbornMutationSteroid 21-HydroxylaseCYP21A2 protein, humanSteroid 21-Hydroxylasecongenital adrenal hyperplasiaconsurfCYP21A2in silicoprotein structureVUS

Identifiers

PMID32824094
PMCPMC7461554
OpenAlexW3049593152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.