ArticleInternational journal of molecular sciences2020
Association between Acrylamide Metabolites and Cardiovascular Risk in Children With Early Stages of Chronic Kidney Disease.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Ambulatory arterial stiffness index among children and adolescents with chronic kidney disease: a report from the Chronic Kidney Disease in Children Study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Ambulatory arterial stiffness index among children and adolescents with chronic kidney disease a report from the Chronic Kidney Disease in Children Study.Research square · 2026Article
- Lactoferrin in Pediatric Chronic Kidney Disease and Its Relationship with Cardiovascular Risk.Children (Basel, Switzerland) · 2024Article
- Green Synthesized Zinc Oxide Nanoparticles Attenuate Acrylamide-Induced Cardiac Injury via Controlling Endoplasmic Reticulum Stress-Associated Apoptosis Through ATF3/CHOP/BCL2 Signaling in Rats.Biological trace element research · 2024Article
- Article
- Asymmetric and Symmetric Dimethylarginines as Renal Function Parameters in Paediatric Kidney Diseases: A Literature Review from 2003 to 2022.Children (Basel, Switzerland) · 2022Review
- Cardiovascular Risks of Hypertension: Lessons from Children with Chronic Kidney Disease.Children (Basel, Switzerland) · 2022Review
- Hypertension and Cardiovascular Diseases: From Etiopathogenesis to Potential Therapeutic Targets.International journal of molecular sciences · 2022Article
- Total cholesterol: a potential mediator of the association between exposure to acrylamide and hypertension risk in adolescent females.Environmental science and pollution research international · 2022Article
- Vitamin D mediates the association between acrylamide hemoglobin biomarkers and obesity.Environmental science and pollution research international · 2022Article
- The Association Between Exposure to Acrylamide and Mortalities of Cardiovascular Disease and All-Cause Among People With Hyperglycemia.Frontiers in cardiovascular medicine · 2022Article
- Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population.International journal of environmental research and public health · 2021Article
- Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study.Toxics · 2021Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Cardiovascular disease (CVD) begins early in children with chronic kidney disease (CKD). Reduced nitric oxide (NO) bioavailability has been associated with increased CVD in CKD patients. Children tend to have more exposure to acrylamide, one of the most common toxins in food. We aimed to determine whether urinary levels of acrylamide metabolites N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA) and N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-cysteine (GAMA) are associated with CV risk markers in children with CKD. Data on 112 children and adolescents ages three to 18 years old with CKD stage G1-G4 are reported. We observed that 24 h ambulatory blood pressure monitoring (ABPM) abnormalities were greater, and left ventricular (LV) mass and ambulatory arterial stiffness index (AASI) were higher in children with CKD stage G2-G4 versus G1. Patients with CKD stage G2-G4 had a lower urinary acrylamide level, but a higher AAMA-to-GAMA ratio than those with CKD stage G1. Urinary acrylamide level was negatively associated with high systolic blood pressure (SBP) and diastolic BP (DBP) load on 24 h ABPM. Lower urinary levels of acrylamide, AAMA, and GAMA were correlated with LV mass. Additionally, GAMA are superior to AAMA related to NO-related parameters, namely citrulline and symmetric dimethylarginine (SDMA). This study suggests that determinations of urinary acrylamide level and its metabolites in the early stages of pediatric CKD may identify patients at risk of CVD. Further studies should clarify mechanisms underlying acrylamide exposure to define the treatment for protection against CVD.
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