Evidence map›Paper›PMID 32824017›Full record

ArticleJournal of functional biomaterials2020

Electrospun Scaffolds Containing Silver-Doped Hydroxyapatite with Antimicrobial Properties for Applications in Orthopedic and Dental Bone Surgery.

Thomas E Paterson, Rui Shi, Jingjing Tian, Caroline J Harrison, Mailys De Sousa Mendes, Paul V Hatton, Zhou Li, Ilida Ortega

Open access · goldAbstract read
In one paragraph

Article in Journal of functional biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

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  15. Review
  16. An Updated Review on Silver Nanoparticles in Biomedicine.Nanomaterials (Basel, Switzerland) · 2020
    Review
  17. Bacterial Interactions with Dental and Medical Materials.Journal of functional biomaterials · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Thomas E PatersonSchool of Clinical Dentistry, University of Sheffield, Shefield 0114, UK.
Rui ShiBeijing Laboratory of Biomedical Materials, Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing 100083, China.
Jingjing TianBeijing Key Laboratory of Micro-nano Energy and Sensor, Beijing institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China.
Caroline J HarrisonSchool of Clinical Dentistry, University of Sheffield, Shefield 0114, UK.
Mailys De Sousa MendesCertara, Simcyp division, Sheffield 0114, UK.
Paul V HattonSchool of Clinical Dentistry, University of Sheffield, Shefield 0114, UK.
Zhou LiBeijing Key Laboratory of Micro-nano Energy and Sensor, Beijing institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China.ORCID 0000-0002-9952-7296
Ilida OrtegaSchool of Clinical Dentistry, University of Sheffield, Shefield 0114, UK.
University of Sheffield · GBChinese Academy of Sciences · CNPeking University · CNSimcyp (United Kingdom) · GB

Funding

Beijing Municipal Health Commission BMC2018-4Beijing Municipal Health Commission PXM2018026275000001Beijing Talent Fund 2016000012113ZK34Engineering and Physical Sciences Research Council EP/K029592/1National Natural Science Foundation of China 51673029National Natural Science Foundation of China 61875015
6 · The paper itself

Abstract

Preventing the development of osteomyelitis while enhancing bone regeneration is challenging, with relatively little progress to date in translating promising technologies to the clinic. Nanoscale hydroxyapatite (nHA) has been employed as a bone graft substitute, and recent work has shown that it may be modified with silver to introduce antimicrobial activity against known pathogens. The aim of this study was to incorporate silver-doped nHA into electrospun scaffolds for applications in bone repair. Silver-doped nHA was produced using a modified, rapid mixing, wet precipitation method at 2, 5, 10 mol.% silver. The silver-doped nHA was added at 20 wt.% to a polycaprolactone solution for electrospinning. Bacteria studies demonstrated reduced bacterial presence, with

Indexed as

antimicrobialbone regenerationelectrospinningnano-hydroxyapatitesilvertoxicity

Identifiers

PMID32824017
PMCPMC7563183
OpenAlexW3049424564

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.