ArticleSensors (Basel, Switzerland)2020
Simple and Cost-Effective Electrochemical Method for Norepinephrine Determination Based on Carbon Dots and Tyrosinase.
Article in Sensors (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 49 citations in OpenAlex.
- Tyrosinase Immobilization Strategies for the Development of Electrochemical Biosensors-A Review.Nanomaterials (Basel, Switzerland) · 2023Review
- Advances on Hormones and Steroids Determination: A Review of Voltammetric Methods since 2000.Membranes · 2022Review
- Studies on the Detection of Oleuropein from Extra Virgin Olive Oils Using Enzymatic Biosensors.International journal of molecular sciences · 2022Article
- New Trends in Fluorescent Nanomaterials-Based Bio/Chemical Sensors for Neurohormones Detection-A Review.ACS omega · 2022Review
- Novel Amperometric Biosensor Based on Tyrosinase/Chitosan Nanoparticles for Sensitive and Interference-Free Detection of Total Catecholamine.Biosensors · 2022Article
- Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots.Polymers · 2022Review
- Microneedle-based nanoporous gold electrochemical sensor for real-time catecholamine detection.Mikrochimica acta · 2022Article
- Perspective-Electrochemical Sensors for Neurotransmitters and Psychiatrics: Steps toward Physiological Mental Health Monitoring.Journal of the Electrochemical Society · 2022Article
- Applications of Carbon Dots for the Photocatalytic and Electrocatalytic Reduction of COMolecules (Basel, Switzerland) · 2022Review
- Intrinsic Blue Fluorescence of 2.0G PAMAM-DCM Polymer Dots and Its Applications for FeSensors (Basel, Switzerland) · 2022Article
- Scientific Developments and New Technological Trajectories in Sensor Research.Sensors (Basel, Switzerland) · 2021Article
- Advances in the Methods for the Synthesis of Carbon Dots and Their Emerging Applications.Polymers · 2021Review
- Engineered tyrosinases with broadened bio-catalysis scope: immobilization using nanocarriers and applications.3 Biotech · 2021Review
- Forensic Biochemical Markers to Evaluate the Agonal Period: A Literature Review.Molecules (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although neurotransmitters are present in human serum at the nM level, any dysfunction of the catecholamines concentration may lead to numerous serious health problems. Due to this fact, rapid and sensitive catecholamines detection is extremely important in modern medicine. However, there is no device that would measure the concentration of these compounds in body fluids. The main goal of the present study is to design a simple as possible, cost-effective new biosensor-based system for the detection of neurotransmitters, using nontoxic reagents. The miniature Au-E biosensor was designed and constructed through the immobilization of tyrosinase on an electroactive layer of cysteamine and carbon nanoparticles covering the gold electrode. This sensing arrangement utilized the catalytic oxidation of norepinephrine (NE) to NE quinone, measured with voltammetric techniques: cyclic voltammetry and differential pulse voltammetry. The prepared bio-system exhibited good parameters: a broad linear range (1-200 μM), limit of detection equal to 196 nM, limit of quantification equal to 312 nM, and high selectivity and sensitivity. It is noteworthy that described method was successfully applied for NE determination in real samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.