Evidence map›Paper›PMID 32823921›Full record

ArticleJournal of personalized medicine2020

Behavioral and Psychological Symptoms of Dementia (BPSD): Clinical Characterization and Genetic Correlates in an Italian Alzheimer's Disease Cohort.

Catia Scassellati, Miriam Ciani, Carlo Maj, Cristina Geroldi, Orazio Zanetti, Massimo Gennarelli, Cristian Bonvicini

Registry-linked trialAbstract read
In one paragraph

Article in Journal of personalized medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07305415 (Integrative Therapeutic Programme to Regulate Expressed Emotions Among Informal Caregivers of People With Dementia), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07305415 narecruitingnot on this mapstarted 2025, after this paper: background citation

Integrative Therapeutic Programme to Regulate Expressed Emotions Among Informal Caregivers of People With Dementia: a Pilot Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2025 to 2027Enrolled56ConditionsBPSD (Behavioral and Psycological Symptoms of Dementia), Expressed Emotion, Depressive Symptom, Caregiving StressArmsCaregivers Of dementia Processing Emotions (COPE)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Glial Cells in Behavioral and Psychological Symptoms of Alzheimer's Disease.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. ΔJournal of clinical medicine · 2024
    Review
  8. Review
  9. Article
  10. Emotional and Neuropsychiatric Disorders Associated with Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  11. Review
  12. Article
  13. Personalizing the Care and Treatment of Alzheimer's Disease: An Overview.Pharmacogenomics and personalized medicine · 2021
    Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Catia ScassellatiGenetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25123 Brescia, Italy.
Miriam CianiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25123 Brescia, Italy.ORCID 0000-0002-6780-1799
Carlo MajGenetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25123 Brescia, Italy.
Cristina GeroldiAlzheimer's Research Unit-Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25123 Brescia, Italy.
Orazio ZanettiAlzheimer's Research Unit-Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25123 Brescia, Italy.
Massimo GennarelliGenetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25123 Brescia, Italy.
Cristian BonviciniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25123 Brescia, Italy.ORCID 0000-0003-1577-2823

Funding

Ministero della Salute Ricerca Corrente
6 · The paper itself

Abstract

backgroundThe occurrence of Behavioral and Psychological Symptoms of Dementia (BPSD) in Alzheimer's Disease (AD) patients hampers the clinical management and exacerbates the burden for caregivers. The definition of the clinical distribution of BPSD symptoms, and the extent to which symptoms are genetically determined, are still open to debate. Moreover, genetic factors that underline BPSD symptoms still need to be identified. PURPOSE: To characterize our Italian AD cohort according to specific BPSD symptoms as well as to endophenotypes. To evaluate the associations between the considered BPSD traits and

methodsAD patients (

results

conclusionsWe strongly suggest the combined use of both BPSD single symptoms/endophenotypes and the "gene

Indexed as

Alzheimer’s disease (AD)APOEbehavioral and psychological symptoms of dementia (BPSD)CART analysisCOMTendophenotypesgenetic variantsMTHFRneuropsychiatry inventory scale (NPI)

Identifiers

PMID32823921
PMCPMC7563608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.