Evidence map›Paper›PMID 32823905›Full record

ArticleInternational journal of molecular sciences2020

Association of Maternal Regulatory Single Nucleotide Polymorphic CD99 Genotype with Preeclampsia in Pregnancies Carrying Male Fetuses in Ethiopian Women.

Tsehayneh Kelemu, Lena Erlandsson, Daniel Seifu, Markos Abebe, Sisay Teklu, Jill R Storry, Stefan R Hansson

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  7. Pathogenesis of Pregnancy-Related Complications 1.0 and 2.0.International journal of molecular sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Tsehayneh KelemuDepartment of Biochemistry, College of Health Sciences, Addis Ababa University, P.O. Box 9086 Addis Ababa, Ethiopia.ORCID 0000-0001-9468-9512
Lena ErlandssonDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences Lund, Lund University, 221 85 Lund, Sweden.
Daniel SeifuDepartment of Biochemistry, College of Health Sciences, Addis Ababa University, P.O. Box 9086 Addis Ababa, Ethiopia.
Markos AbebeArmauer Hanson Research Institute, P.O. Box 1005 Addis Ababa, Ethiopia.
Sisay TekluDepartment of Obstetrics and Gynecology, College of Health Sciences, Addis Ababa University, P.O. Box 9086 Addis Ababa, Ethiopia.
Jill R StorryDepartment of Hematology and Transfusion Medicine, Division of Laboratory Medicine, Lund University, 221 85 Lund, Sweden.
Stefan R HanssonDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences Lund, Lund University, 221 85 Lund, Sweden.ORCID 0000-0002-7838-9074
Lund University · SEAddis Ababa University · ETArmauer Hansen Research Institute · ETUniversity of Global Health Equity · RW

Funding

NORAD Norwegian Agency for Development Cooperation (NORAD)SIDA Swedish International Development Agency (SIDA)
6 · The paper itself

Abstract

Preeclampsia (PE) is a human specific syndrome with unknown etiology causing maternal and fetal morbidities and mortalities. In PE, maternal inflammatory responses are more exaggerated if the fetus is male than female. Other pregnancy complications such as spontaneous abortions are also more common if the fetus is male. Recent transcriptome findings showed an increased expression of CD99 in erythroid cells from male cord blood in PE. The single nucleotide polymorphism (SNP) rs311103, located in a GATA-binding site in a regulatory region on the X/Y chromosomes, governs a coordinated expression of the Xg blood group members CD99 and Xg

Indexed as

Genetic Association StudiesGenetic Predisposition to Disease12E7 AntigenAdultEthiopiaFemaleFetusGene FrequencyHumansMalePolymorphism, Single NucleotidePre-EclampsiaPregnancyPregnancy Outcome12E7 AntigenCD99 protein, humanCD99GATA3male fetuspreeclampsiaSNP

Identifiers

PMID32823905
PMCPMC7461595
OpenAlexW3049717713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.