Evidence map›Paper›PMID 32823834›Full record

ArticleJournal of clinical medicine2020

Hospitalizations for Acute Salicylate Intoxication in the United States.

Charat Thongprayoon, Tananchai Petnak, Wisit Kaewput, Michael A Mao, Karthik Kovvuru, Swetha R Kanduri, Boonphiphop Boonpheng, Tarun Bathini, Saraschandra Vallabhajosyula, Aleksandra I Pivovarova and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Charat ThongprayoonDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Tananchai PetnakDivision of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Wisit KaewputDepartment of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.ORCID 0000-0003-2920-7235
Michael A MaoDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-1814-7003
Karthik KovvuruDepartment of Medicine, Ochsner Medical Center, New Orleans, LA 70121, USA.
Swetha R KanduriDepartment of Medicine, Ochsner Medical Center, New Orleans, LA 70121, USA.ORCID 0000-0002-7190-6665
Boonphiphop BoonphengDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Tarun BathiniDepartment of Internal Medicine, University of Arizona, Tucson, AZ 85721, USA.
Saraschandra VallabhajosyulaSection of Interventional Cardiology, Division of Cardiovascular Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Aleksandra I PivovarovaDivision of Nephrology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0002-1335-7696
Himmat S BrarDivision of Nephrology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Juan MedauraDivision of Nephrology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Wisit CheungpasitpornDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-9954-9711
University of Mississippi Medical Center · USMayo Clinic · USOchsner Medical Center · USEmory University · USMahidol University · THMayo Clinic in Florida · USPhramongkutklao Hospital · THUniversity of Arizona · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to describe inpatient prevalence, characteristics, outcomes, and resource use for acute salicylate intoxication hospitalizations in the United States.

methodsA total of 13,805 admissions with a primary diagnosis of salicylate intoxication from 2003 to 2014 in the National Inpatient Sample database were analyzed. Prognostic factors for in-hospital mortality were determined using multivariable logistic regression.

resultsThe overall inpatient prevalence of salicylate intoxication among hospitalized patients was 147.8 cases per 1,000,000 admissions in the United States. The average age was 34 ± 19 years. Of these, 35.0% were male and 65.4% used salicylate for suicidal attempts. Overall, 6% required renal replacement therapy. The most common complications of salicylate intoxication were electrolyte and acid-base disorders, including hypokalemia (25.4%), acidosis (19.1%), and alkalosis (11.1%). Kidney failure (9.3%) was the most common observed organ dysfunction. In-hospital mortality was 1.0%. Increased in-hospital mortality was associated with age ≥30, Asian/Pacific Islander race, diabetes mellitus, hyponatremia, ventricular arrhythmia, kidney failure, respiratory failure, and neurological failure, while decreased in-hospital mortality was associated with African American and Hispanic race.

conclusionhospitalization for salicylate intoxication occurred in 148 per 1,000,000 admissions in the United States. Several factors were associated with in-hospital mortality.

Indexed as

epidemiologyhospitalizationoutcomessalicylatesalicylate intoxication

Identifiers

PMID32823834
PMCPMC7465677
OpenAlexW3048865585

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.