ArticleMetabolites2020
Antibiotics Effects on the Fecal Metabolome in Preterm Infants.
Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Trial
- Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome.Cell host & microbe · 2024Trial
- Longitudinal fecal amino acid profiles in extremely preterm infants: early-life determinants and associations with late-onset sepsis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Effects of Skim Milk Whey-Derived Proteins on Plasma, Urine, and Gut Metabolites in Preterm Piglets as a Model for Infants.Molecular nutrition & food research · 2025Article
- The changing metabolic landscape of bile acids - keys to metabolism and immune regulation.Nature reviews. Gastroenterology & hepatology · 2024Review
- Identification of Novel Biomarkers in Late Preterm Neonates with Respiratory Distress Syndrome (RDS) Using Urinary Metabolomic Analysis.Metabolites · 2023Article
- Fecal Volatile Metabolomics Predict Gram-Negative Late-Onset Sepsis in Preterm Infants: A Nationwide Case-Control Study.Microorganisms · 2023Article
- Longitudinal profiles of the fecal metabolome during the first 2 years of life.Scientific reports · 2023Article
- The potential role of early life feeding patterns in shaping the infant fecal metabolome: implications for neurodevelopmental outcomes.npj metabolic health and disease · 2023Article
- Bile Acid Regulates Mononuclear Phagocytes and T Helper 17 Cells to ControlJournal of fungi (Basel, Switzerland) · 2022Article
- Probiotic characterization of Lactiplantibacillus plantarum HOM3204 and its restoration effect on antibiotic-induced dysbiosis in mice.Letters in applied microbiology · 2022Article
- Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis.Antimicrobial resistance and infection control · 2022Article
- Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity.mBio · 2022Article
- The Serum and Fecal Metabolomic Profiles of Growing Kittens Treated with Amoxicillin/Clavulanic Acid or Doxycycline.Animals : an open access journal from MDPI · 2022Article
- Inferring early-life host and microbiome functions by mass spectrometry-based metaproteomics and metabolomics.Computational and structural biotechnology journal · 2022Review
- Bile Acid Regulates the Colonization and Dissemination ofJournal of fungi (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Within a randomized prospective pilot study of preterm infants born at less than 33 weeks' gestation, weekly fecal samples from 19 infants were collected and metabolomic analysis was performed. The objective was to evaluate for differences in fecal metabolites in infants exposed to antibiotics vs. not exposed to antibiotics in the first 48 h after birth. Metabolomics analysis was performed on 123 stool samples. Significant differences were seen in the antibiotics vs. no antibiotics groups, including pathways related to vitamin biosynthesis, bile acids, amino acid metabolism, and neurotransmitters. Early antibiotic exposure in preterm infants may alter metabolites in the intestinal tract of preterm infants. Broader multi-omic studies that address mechanisms will guide more prudent antibiotic use in this population.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.