ArticleAntibiotics (Basel, Switzerland)2020
The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products.
Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- OSMAC guided bioprospecting of Atlantic sponges reveals novel bacterial species and evidence for the antimicrobial thiazole alkaloid agrochelin II.Applied and environmental microbiology · 2026Article
- New insights into the microbiome of the deep-sea spongeMicrobial genomics · 2026Article
- The Kocurious case of Noodlococcus: genomic insights intoMicrobial genomics · 2025Article
- Article
- Impact of growth conditions on the abundance and diversity of cultivable bacteria recovered fromFEMS microbes · 2025Article
- Diversity and structure of the deep-sea sponge microbiome in the equatorial Atlantic Ocean.Microbiology (Reading, England) · 2024Article
- Discovery and biosynthetic assessment of 'Microbial genomics · 2023Article
- Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential.FEMS microbes · 2023Article
- On the Hunt for Next-Generation Antimicrobial Agents: An Online Symposium Organized Jointly by the French Society for Medicinal Chemistry (Société de Chimie Thérapeutique) and the French Microbiology Society (Société Française de Microbiologie) on 9-10 December 2021.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Identification of BgP, a Cutinase-Like Polyesterase From a Deep-Sea Sponge-Derived Actinobacterium.Frontiers in microbiology · 2022Article
- A NewMarine drugs · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due to the significant logistical and operational challenges associated with accessing the deep ocean, bioprospecting programmes that seek to generate novel products from marine organisms have, to date, focused predominantly on samples recovered from shallow seas. For this reason, the deep ocean remains a largely untapped resource of novel microbiological life and associated natural products. Here we report the establishment of the Bristol Sponge Microbiome Collection (BISECT), a unique repository of deep-sea microorganisms and associated metabolites isolated from the microbiota of marine sponges, recovered from previously unsurveyed regions of the mid Atlantic Ocean, at depths of 0.3-3 km. An integrated biodiscovery pipeline comprising molecular, genetic, bioinformatic and analytical tools is also described, which is being applied to interrogate this collection. The potential of this approach is illustrated using data reporting our initial efforts to identify antimicrobial natural product lead compounds. Prospects for the use of BISECT to address allied pharmaceutical needs, along with mechanisms of access to the collection are also discussed.
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