ArticleMaterials (Basel, Switzerland)2020
Diclofenac Embedded in Silk Fibroin Fibers as a Drug Delivery System.
Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Organic-Inorganic Hybridization of Silkworm Cocoon Filaments Using Nano Pastes of Silica-Phosphate-M (M = Cu, Fe, or Al).Nanomaterials (Basel, Switzerland) · 2024Article
- Exploring Protein-Based Carriers in Drug Delivery: A Review.Pharmaceutics · 2024Review
- Optimization of Diclofenac-Loaded Bicomponent Nanofibers: Effect of Gelatin on In Vitro and In Vivo Response.Pharmaceutics · 2024Article
- Polymer-Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface Modifications.Pharmaceutics · 2024Review
- Applications and Potentials of a Silk Fibroin Nanoparticle Delivery System in Animal Husbandry.Animals : an open access journal from MDPI · 2024Review
- Development of nanostructured formulation from naringenin and silk fibroin and application for inhibition of lipoxygenase (LOX).RSC advances · 2023Article
- Photoluminescent Gold/BSA Nanoclusters (AuNC@BSA) as Sensors for Red-Fluorescence Detection of Mycotoxins.Materials (Basel, Switzerland) · 2022Article
- Applications of Novel Biodegradable Polymeric Materials.Materials (Basel, Switzerland) · 2022Article
- Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges.Cells · 2022Review
- Electrospun Poly(ethylene Terephthalate)/Silk Fibroin Composite for Filtration Application.Polymers · 2021Article
- Application of an ultrasound semi-quantitative assessment in the degradation of silk fibroin scaffolds in vivo.Biomedical engineering online · 2021Article
- The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application.Nanomaterials (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silk fibroin is a biocompatible, non-toxic, mechanically robust protein, and it is commonly used and studied as a material for biomedical applications. Silk fibroin also gained particular interest as a drug carrier vehicle, and numerous silk formats have been investigated for this purpose. Herein, we have prepared electrospun nanofibers from pure silk fibroin and blended silk fibroin/casein, followed by the incorporation of an anti-inflammatory drug, diclofenac. Casein serves as an excipient in pharmaceutical products and has a positive effect on the gradual release of drugs. The characteristics of the investigated composites were estimated by scanning electron microscope, transmission electron microscope, thermogravimetric analysis, and a lifetime of diclofenac by electron paramagnetic resonance analysis. The cumulative release in vitro of diclofenac sodium salt, together with the antiproliferative effect of diclofenac sodium salt-loaded silk nanofibers against the growth of two cancer cell lines, are presented and discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.