Evidence map›Paper›PMID 32823606›Full record

Trial reportNutrients2020

Multiple Micronutrients and Docosahexaenoic Acid Supplementation during Pregnancy: A Randomized Controlled Study.

Maddalena Massari, Chiara Novielli, Chiara Mandò, Stefania Di Francesco, Matteo Della Porta, Roberta Cazzola, Mauro Panteghini, Valeria Savasi, Silvia Maggini, Ella Schaefer and 1 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

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  14. Dietary supplements and vascular function in hypertensive disorders of pregnancy.Pflugers Archiv : European journal of physiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Maddalena MassariDepartment of Woman, Mother and Neonate, Buzzi Children Hospital, ASST Fatebenefratelli Sacco, 20154 Milan, Italy.
Chiara Novielli"Luigi Sacco" Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, 20157 Milan, Italy.ORCID 0000-0002-3570-8290
Chiara Mandò"Luigi Sacco" Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, 20157 Milan, Italy.ORCID 0000-0003-3458-3075
Stefania Di FrancescoDepartment of Woman, Mother and Neonate, Buzzi Children Hospital, ASST Fatebenefratelli Sacco, 20154 Milan, Italy.
Matteo Della Porta"Luigi Sacco" Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, 20157 Milan, Italy.ORCID 0000-0002-1984-1614
Roberta Cazzola"Luigi Sacco" Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, 20157 Milan, Italy.ORCID 0000-0002-0778-8529
Mauro Panteghini"Luigi Sacco" Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, 20157 Milan, Italy.
Valeria SavasiDepartment of Woman, Mother and Neonate, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Silvia MagginiBayer Consumer Care AG, 4002 Basel, Switzerland.
Ella SchaeferBayer Consumer Care AG, 4002 Basel, Switzerland.ORCID 0000-0002-4872-2892
Irene CetinDepartment of Woman, Mother and Neonate, Buzzi Children Hospital, ASST Fatebenefratelli Sacco, 20154 Milan, Italy.
Luigi Sacco Hospital · ITBayer (Switzerland) · CHASST Fatebenefratelli Sacco · IT

Funding

Bayer Consumer Care AG, Basel, Switzerland NA
6 · The paper itself

Abstract

Maternal dietary intake during pregnancy needs to meet increased nutritional demands to maintain metabolism and to support fetal development. Docosahexaenoic acid (DHA) is essential for fetal neuro-/visual development and in immunomodulation, accumulating rapidly within the developing brain and central nervous system. Levels available to the fetus are governed by the maternal diet. In this multicenter, parallel, randomized controlled trial, we evaluated once-daily supplementation with multiple micronutrients and DHA (i.e., multiple micronutrient supplementation, MMS) on maternal biomarkers and infant anthropometric parameters during the second and third trimesters of pregnancy compared with no supplementation. Primary efficacy endpoint: change in maternal red blood cell (RBC) DHA (

Indexed as

Dietary SupplementsMaternal Nutritional Physiological PhenomenaAdolescentAdultBiomarkersDocosahexaenoic AcidsFemaleFetal BloodFetal DevelopmentHumansInfant, NewbornMicronutrientsNutritional StatusPregnancyPregnancy TrimestersPrenatal CareBiomarkersDocosahexaenoic AcidsMicronutrientsVitamin Ddocosahexaenoic acidlong-chain polyunsaturated fatty acidsmaternal biomarkersmicronutrientsneurodevelopmentpregnant womensupplementationvitamin D

Identifiers

PMID32823606
PMCPMC7468952
OpenAlexW3048926273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.