ArticleLife (Basel, Switzerland)2020
Protoenzymes: The Case of Hyperbranched Polymer-Scaffolded ZnS Nanocrystals.
Article in Life (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Recent progress in primitive polyester synthesis and membraneless microdroplet assembly.Biophysics and physicobiology · 2023Article
- A Physicochemical Consideration of Prebiotic Microenvironments for Self-Assembly and Prebiotic Chemistry.Life (Basel, Switzerland) · 2022Review
- Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life.Nature communications · 2021Article
- Introduction-First Billion Years: Habitability.Astrobiology · 2021Review
- The Grayness of the Origin of Life.Life (Basel, Switzerland) · 2021Article
- Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine.RSC advances · 2021Article
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3 authors.
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Abstract
Enzymes are biological catalysts that are comprised of small-molecule, metal, or cluster catalysts augmented by biopolymeric scaffolds. It is conceivable that early in chemical evolution, ancestral enzymes opted for simpler, easier to assemble scaffolds. Herein, we describe such possible protoenzymes: hyperbranched polymer-scaffolded metal-sulfide nanocrystals. Hyperbranched polyethyleneimine (HyPEI) and glycerol citrate polymer-supported ZnS nanocrystals (NCs) are formed in a simple process. Transmission electron microscopy (TEM) analyses of HyPEI-supported NCs reveal spherical particles with an average size of 10 nm that undergo only a modest aggregation over a 14-day incubation. The polymer-supported ZnS NCs are shown to possess a high photocatalytic activity in an eosin B photodegradation assay, making them an attractive model for the study of the origin of life under the "Zn world" theory dominated by a photocatalytic proto-metabolic redox reaction network. The catalyst, however, could be easily adapted to apply broadly to different protoenzymatic systems.
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Registered trials
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